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Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride: For Improved Efficacy Using Disintegrant Blends - Softcover

Chapla, Nikunj; Chapla, Vishal; Pujara, Naisarg

 
9783659346040: Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride: For Improved Efficacy Using Disintegrant Blends
Softcover
ISBN 10: 3659346047 ISBN 13: 9783659346040
Verlag: LAP LAMBERT Academic Publishing, 2013

Inhaltsangabe

Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is fast dissolving tablets (FDT) of Phenylephrine Hydrochloride, a selective α1 adrenergic receptor antagonist, used for nasal decongestant and producing mydriasis effect. In present work an attempt has been made by formulating fast dissolving tablets of Phenylephrine Hydrochloride by superdisintegrants addition method using croscarmellose sodium, crospovidone and sodium starch glycolate. A total of 10 batches were prepared by using various combination and concentration of superdisintegrants and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release studies, kinetic studies and stability studies. Amongst all the formulations F2 and F9 were found to be better formulations which include single superdisintegrants and combination of superdisintegrants. Finally it was concluded that FDT of Phenylephrine Hydrochloride will be used as a novel drug dosage form for pediatrics and geriatrics.

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Über die Autorin bzw. den Autor

Nikunj Chapla, completed Master of Pharmacy, Pharmaceutics from Department of Pharmaceutics, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences Deralakatte, Mangalore at NITTE University.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2013
Sprache
Englisch
ISBN 10 
3659346047
ISBN 13 
9783659346040
Einband
Taschenbuch
Anzahl der Seiten
148
Kontakt zum Hersteller
preigu GmbH & Co. KG
mail@preigu.de

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