Formulation, Development & Evaluation of Multi-compartment Dosage Form: For Immediate Relief From Hypertension - Softcover

Pujara, Naisarg; Parmar, Ramesh

 
9783659410475: Formulation, Development & Evaluation of Multi-compartment Dosage Form: For Immediate Relief From Hypertension
Softcover
ISBN 10: 3659410470 ISBN 13: 9783659410475
Verlag: LAP LAMBERT Academic Publishing, 2013

Inhaltsangabe

In the present study, formulation of multi-compartment dosage form containing soft gelatin capsule of Nifedipine, granules of Losartan potassium and fast disintegrating tablet of Hydrochlorothiazide was designed to achieve immediate release of drug from the dosage form, to increase therapeutic efficacy and to improve patient compliance in case of hypertension. Triple combination of antihypertensive drugs induces superior reduction in blood pressure as compared to conventional dosage form. The basic aim of this work is to produce immediate release action of drug from the hard gelatin capsule containing soft gelatin capsule of Nifedipine, granules of Losartan potassium and fast disintegrating tablet of Hydrochlorothiazide. Soft gelatin capsule was prepared by encapsulation method using propylene glycol and PEG 400 as solubilizing agents. The granules were prepared by wet granulation method using PVP K30 as binder. The fast disintegrating tablets were prepared by direct compression method using croscarmellose sodium and crospovidone as super disintegrating agents. Multi-compartment dosage form was considered as optimized formulation for immediate release of antihypertensive drugs.

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Über die Autorin bzw. den Autor

Naisarg D. Pujara, Master of Pharmacy, Pharmaceutics at Gujarat Technological University. Pharmacy Scholar at S. J. Thakkar Pharmacy College, Rajkot, Gujarat, India. Published Five International Books, Seven National & International Research articles and Five National & International Review articles. Reviewer of Two Elsevier Journals.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2013
Sprache
Englisch
ISBN 10 
3659410470
ISBN 13 
9783659410475
Einband
Taschenbuch
Anzahl der Seiten
188
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
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Brivibas gatve 197
Riga
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