Calcium Channel Blockers Against MPTP Induced Parkinson’s In Rats - Softcover

Kumar, Puneet; Mehta, Ankita; Deshmukh, Rahul

 
9783659536762: Calcium Channel Blockers Against MPTP Induced Parkinson’s In Rats
Softcover
ISBN 10: 3659536768 ISBN 13: 9783659536762
Verlag: LAP LAMBERT Academic Publishing, 2014

Inhaltsangabe

The present study has been designed to investigate the protective effect of calcium channel blockers against MPTP - induced Parkinson’s disease-like symptoms in rats. The novel protocol showed that repeated bilateral infusion of MPTP into the SNpc by stereotactic surgery caused degeneration of nigrostriatal dopaminergic neurons. Body weight and behavioral parameters (locomotor, rotarod and activity on narrow beam walk) were assessed on 14th, 21st and 28th day post-MPTP administration. Malondialdehyde, nitrite concentration, superoxide dismutase, catalase levels and Cytokines level (TNF-α and IL-1β) were measured on the 28th day. Administration of MPTP significantly impaired behavioral and biochemical parameters, suggesting significant mitochondrial dysfunction as compared to sham control rats. Further, increased level of TNF-α and IL-1β conferred neuroinflammation after MPTP administration in brain. Post treatment with cilnidipine dual L- and N- type and verapamil L-type for 14 days significantly improved behavioral parameters and oxidative damage as compared to MPTP-treated group. Calcium channel blockers treatment also reduced the cytokine levels in brain.

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Über die Autorin bzw. den Autor

Dr. Puneet Kumar M. Pharm., PDCR., Ph.D., working as Associate Professor at ISF College of Pharmacy Moga, Punjab, India. Presently, Dr. Kumar involves in research and teaching both at graduate and post graduate level. He clinched two research grants for worth of 4.3 million rupees from AICTE and DST (fast Track for Young Scientist).

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2014
Sprache
Englisch
ISBN 10 
3659536768
ISBN 13 
9783659536762
Einband
Taschenbuch
Anzahl der Seiten
84
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

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Riga
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