Formulation Of Phenytoin Complexes For Dissolution Enhancement: Inclusion Complexation Using Β-cyclodextrin And Hp Β-cyclodextrin: Inclusion Complexation Using �-cyclodextrin And Hp �-cyclodextrin - Softcover

Maulika, Patel ; Kalpen, Patel

9783659537059: Formulation Of Phenytoin Complexes For Dissolution Enhancement: Inclusion Complexation Using Β-cyclodextrin And Hp Β-cyclodextrin: Inclusion Complexation Using �-cyclodextrin And Hp �-cyclodextrin

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ISBN 10: 3659537055 ISBN 13: 9783659537059

Verlag: LAP LAMBERT Academic Publishing, 2014

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Phenytoin Inclusion complex prepared by microwave method was used for preparation of FDT by different superdisintegrants by direct compression method. From that the cross-povidone (5%) containing inclusion complex was maximum DT, Wetting time and In-vitro drug release. The FDT containing 1:2 ratio complexes and 5% crospovidone give minimum DT and Wetting time. Then 32 full factorial designs were applied and the tablets were synthesized using different proportions of inclusion complex and crospovidone (%) by direct compression technique. The optimum ratio was 1:2 and 5% which produced highest DT (10.01 sec), Wetting time (9.45 sec.) and cumulative percent drug release (99.51% at 40 min). The solubility and dissolution pattern of Phenytoin were found to be carrier ratio dependent. From evaluation parameters and formulation characterization, it can be concluded that solubility of drug was improved by MW method compared to SE method and pure drug. The tablet contain optimum ratio of inclusion complex and optimum concentration of superdisintegrants give maximum drug release in minimum time period.

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�ber die Autorin bzw. den Autor

Maulika S Patel, M. Pharmacy in Pharmaceutical Technology in Shree Krishna Institute of Pharmacy, Shankhalpur, becharaji at Gujarat Technological University, Ahmedabad, Gujarat, India.

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Verlag: LAP LAMBERT Academic Publishing
Erscheinungsdatum: 2014
Sprache: Englisch
ISBN 10: 3659537055
ISBN 13: 9783659537059
Einband: Taschenbuch
Anzahl der Seiten: 152
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Formulation Of Phenytoin Complexes For Dissolution Enhancement

Patel Maulika

Verlag: LAP LAMBERT Academic Publishing Mai 2014, 2014

ISBN 10: 3659537055 ISBN 13: 9783659537059

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Phenytoin Inclusion complex prepared by microwave method was used for preparation of FDT by different superdisintegrants by direct compression method. From that the cross-povidone (5%) containing inclusion complex was maximum DT, Wetting time and In-vitro drug release. The FDT containing 1:2 ratio complexes and 5% crospovidone give minimum DT and Wetting time. Then 32 full factorial designs were applied and the tablets were synthesized using different proportions of inclusion complex and crospovidone (%) by direct compression technique. The optimum ratio was 1:2 and 5% which produced highest DT (10.01 sec), Wetting time (9.45 sec.) and cumulative percent drug release (99.51% at 40 min). The solubility and dissolution pattern of Phenytoin were found to be carrier ratio dependent. From evaluation parameters and formulation characterization, it can be concluded that solubility of drug was improved by MW method compared to SE method and pure drug. The tablet contain optimum ratio of inclusion complex and optimum concentration of superdisintegrants give maximum drug release in minimum time period. 152 pp. Englisch. Bestandsnummer des Verk�ufers 9783659537059

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Formulation Of Phenytoin Complexes For Dissolution Enhancement

Patel Maulika|Patel Kalpen

Verlag: LAP LAMBERT Academic Publishing, 2014

ISBN 10: 3659537055 ISBN 13: 9783659537059

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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Maulika PatelMaulika S Patel, M. Pharmacy in Pharmaceutical Technology in Shree Krishna Institute of Pharmacy, Shankhalpur, becharaji at Gujarat Technological University, Ahmedabad, Gujarat, India.Phenytoin Inclusion complex prep. Bestandsnummer des Verk�ufers 5163202

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Formulation Of Phenytoin Complexes For Dissolution Enhancement

Patel Maulika

Verlag: LAP LAMBERT Academic Publishing Mai 2014, 2014

ISBN 10: 3659537055 ISBN 13: 9783659537059

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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Phenytoin Inclusion complex prepared by microwave method was used for preparation of FDT by different superdisintegrants by direct compression method. From that the cross-povidone (5%) containing inclusion complex was maximum DT, Wetting time and In-vitro drug release. The FDT containing 1:2 ratio complexes and 5% crospovidone give minimum DT and Wetting time. Then 32 full factorial designs were applied and the tablets were synthesized using different proportions of inclusion complex and crospovidone (%) by direct compression technique. The optimum ratio was 1:2 and 5% which produced highest DT (10.01 sec), Wetting time (9.45 sec.) and cumulative percent drug release (99.51% at 40 min). The solubility and dissolution pattern of Phenytoin were found to be carrier ratio dependent. From evaluation parameters and formulation characterization, it can be concluded that solubility of drug was improved by MW method compared to SE method and pure drug. The tablet contain optimum ratio of inclusion complex and optimum concentration of superdisintegrants give maximum drug release in minimum time period.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 152 pp. Englisch. Bestandsnummer des Verk�ufers 9783659537059

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Formulation Of Phenytoin Complexes For Dissolution Enhancement : Inclusion Complexation Using �-cyclodextrin And Hp �-cyclodextrin

Patel Maulika

Verlag: LAP LAMBERT Academic Publishing, 2014

ISBN 10: 3659537055 ISBN 13: 9783659537059

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Print-on-Demand

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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Phenytoin Inclusion complex prepared by microwave method was used for preparation of FDT by different superdisintegrants by direct compression method. From that the cross-povidone (5%) containing inclusion complex was maximum DT, Wetting time and In-vitro drug release. The FDT containing 1:2 ratio complexes and 5% crospovidone give minimum DT and Wetting time. Then 32 full factorial designs were applied and the tablets were synthesized using different proportions of inclusion complex and crospovidone (%) by direct compression technique. The optimum ratio was 1:2 and 5% which produced highest DT (10.01 sec), Wetting time (9.45 sec.) and cumulative percent drug release (99.51% at 40 min). The solubility and dissolution pattern of Phenytoin were found to be carrier ratio dependent. From evaluation parameters and formulation characterization, it can be concluded that solubility of drug was improved by MW method compared to SE method and pure drug. The tablet contain optimum ratio of inclusion complex and optimum concentration of superdisintegrants give maximum drug release in minimum time period. Bestandsnummer des Verk�ufers 9783659537059

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