Pulmonary Toxicity of MgO Nanoparticles in Rats: Toxicity of MgO Nanomaterials - Softcover

G., Kiranmai; A., Rama Narsimha Reddy

Softcover

ISBN 10: 3659540714 ISBN 13: 9783659540714

Verlag: LAP LAMBERT Academic Publishing, 2014

Inhaltsangabe

The present study investigated the acute pulmonary toxic effects MgO nanoparticle in rats following their exposure through intratracheal instillation, and investigated the oxidative stress and anti-oxidant status in rats following exposure and also to compare these toxic effects with those of quartz particles.Intratracheal instillation method was used to exposure the nanomaterials to the rats and evaluated for various tissue damage markers like alkaline phosphatase (ALP), lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid at 1, 7, 30 days of post exposure intervals. Exposure of nanomaterials caused the dose dependant increase in ALP, LDH activity in BAL fluids of rat lungs indicated the pulmonary toxicity of these nanoparticles, which was supported by the histopathological examinations. Exposure of nanoparticles to rats produced a dose dependant decrease in the levels of TAS, Catalase SOD indicating the induction of oxidative stress.

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Über die Autorin bzw. den Autor

Kiranmai Gelli completed this research work under the guidance of Dr. A. Rama Narsimha Reddy, Professor of Pharmacology, Vaageswari College of Pharmacy, Karimnagar, INDIA. She has 3 articles published in peer reviewed and international journals.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2014
• Sprache: Englisch
• ISBN 10: 3659540714
• ISBN 13: 9783659540714
• Einband: Taschenbuch
• Anzahl der Seiten: 84
• Kontakt zum Hersteller: Nicht verfügbar
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