Cell Cycle Control, Cell Fate Decisions and the Central Nervous System: Implications in Brain Tumour Formation - Softcover

Lubanska, Dorota; Porter, Lisa

 
9783659547782: Cell Cycle Control, Cell Fate Decisions and the Central Nervous System: Implications in Brain Tumour Formation
Softcover
ISBN 10: 3659547786 ISBN 13: 9783659547782
Verlag: LAP LAMBERT Academic Publishing, 2014

Inhaltsangabe

Development of the central nervous system remains under strict control of the cell cycle. Spatial and temporal onset and completion of both neuro- and gliogenesis are regulated by several cell cycle proteins. Importantly, proteins comprising G1 phase regulatory network are involved in the control of stemness and/or lineage commitment balance in the pools of neural stem cells throughout the development. Deviation from this balance may lead to aberrant changes in cell division resulting in formation of brain tumour initiating cells (BTICs) which are at the source of human glioblastoma. This book provides a brief review of the cell cycle regulation at the embryonic and postnatal stages of neural development. Based on recent literature, a discussion on the role of G1 phase cyclins, cell cycle inhibitors and a novel cell cycle regulator, Spy1, in neural cell fate decisions, including mode of division and brain tumour formation, is provided in detail. The content of this book will aid in understanding how normal neural cells rely on cell cycle to control their growth and differentiation throughout life and how aberrant changes to certain cell cycle proteins contribute to gliomagenesis

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Über die Autorin bzw. den Autor

Research Associate at the Department of Biological Sciences at the University of Windsor, Canada, where she obtained her PhD in 2013. Her research involves cell cycle control mechanisms in human glioblastoma and during neurogenesis. Recently published a study in Cancer Cell on cell cycle regulation and mode of division in glioma initiating cells.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2014
Sprache
Englisch
ISBN 10 
3659547786
ISBN 13 
9783659547782
Einband
Taschenbuch
Anzahl der Seiten
88
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland