Advanced glycation inhibitory potential of certain antidiabetic plants - Softcover

Jaggi, Amteshwar; Parkash, Varun; Singh, Nirmal

Softcover

ISBN 10: 3659566330 ISBN 13: 9783659566332

Verlag: LAP LAMBERT Academic Publishing, 2014

Inhaltsangabe

The present study was designed to investigate the antiglycation potential of hydro-alcoholic and alkaloidal fractions of selected plants. Seeds of Trigonella foenum-graecum, bulbs of Allium sativum, fruits of Momordica charantia. and leaves of Gymnema sylvestre were selected. The protein glycation inhibitory activity of these plants was evaluated using glucose-bovine serum albumin assay. Among the hydroalcoholic extracts, Trigonella-foenum graecum showed highest antiglycation activity (IC50 = 53.53 ± 1.24 µg/ml) followed by Allium sativum (IC50 = 68.36 ± 1.56 µg/ml), Momordica charantia (IC50 = 85.16 ± 1.87 µg/ml) and Gymnema sylvestre (IC50 = 103.66 ± 2.09 µg/ml). Among the alkaloidal fractions, the highest antiglycation activity was shown by Trigonella-foenum graecum (IC50 = 31.56 ± 1.36 µg/ml) followed by Allium sativum (IC50 = 40.46 ± 1.59 µg/ml), Momordica charantia (IC50 = 54.8 ± 2.12 µg/ml) and Gymnema sylvestre (IC50 = 64.50 ± 1.73 µg/ml). Aminoguanidine, a standard drug, showed 100% inhibition (IC50 = 22.45 ± 1.89 µg/ml). Alkaloidal extracts of these plants possess antiglycation activity and may be explored in diabetic complications

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The author is Assistant professor in Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala. He has 11 years of experience of teaching and Research.His keen area of interest are neuropathic pain, stress adaptation and diabetic complications.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2014
• Sprache: Englisch
• ISBN 10: 3659566330
• ISBN 13: 9783659566332
• Einband: Taschenbuch
• Anzahl der Seiten: 64
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: VDM Verlag Dr. Müller; customerservice@vdm-vsg.de; ; Brivibas gatve 197; Riga; 1039; Lettland