Formulation and Evaluation of Fast Dissolving Sublingual Tablet: Of Ivabradine Hydrochloride for reduction in ischemic condition in Stable Angina - Softcover

Raval, Brahmdutta; Pujara, Naisarg; Ranpura, Vicky

 
9783659595363: Formulation and Evaluation of Fast Dissolving Sublingual Tablet: Of Ivabradine Hydrochloride for reduction in ischemic condition in Stable Angina
Softcover
ISBN 10: 3659595365 ISBN 13: 9783659595363
Verlag: LAP LAMBERT Academic Publishing, 2014

Inhaltsangabe

The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristic

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Über die Autorin bzw. den Autor

Brahmdutta Raval, Master of Pharmacy, Pharmaceutics. Studied M. Pharm., Pharmaceutics from N R Vekaria Institute of Pharmacy, Junagadh, Gujarat, India under Gujarat Technological University. Published One Review Article in International Peer Reviewed Journal.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2014
Sprache
Englisch
ISBN 10 
3659595365
ISBN 13 
9783659595363
Einband
Taschenbuch
Anzahl der Seiten
116
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

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Riga
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