Formulation Of Drug Delivery Systems Based On Gel-forming Polymers: Preparation and evaluation of degradable, gel-forming Tetracycline HCl films for local treatment of periodontal pockets - Softcover

Kassem, Abeer; Ismail, Fatma; Aboulmagd, Elsayed

 
9783659629785: Formulation Of Drug Delivery Systems Based On Gel-forming Polymers: Preparation and evaluation of degradable, gel-forming Tetracycline HCl films for local treatment of periodontal pockets
Softcover
ISBN 10: 3659629782 ISBN 13: 9783659629785
Verlag: LAP LAMBERT Academic Publishing, 2014

Inhaltsangabe

Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects. This study explored the application of tetracycline HCl (Tc HCl) films based on gel forming polymers as drug release regulators for local treatment of periodontal pockets. Different film formulations were simply prepared by “solvent casting technique”. Films were suitable for intra-pocket application, they were hard enough to be easily inserted into the periodontal pocket. Immediately after application, they hydrate by the action of gingival crevicular fluid forming a bioadhesive gel which allow the formulation to get access to the entire pocket. Films exhibited a sustained release pattern. The stability study for the selected formula (Tc HCl/Na CMC) indicated that the five months storage period did not significantly influence the drug release behavior or its antibacterial activity. Clinical evaluation indicated that the film was well tolerated, no signs of irritation or prolonged foreign body sensation were reported by the test subjects and significant reduction in the pocket depth was observed.

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Über die Autorin bzw. den Autor

Dr. Abeer Ahmed Kassem. Ph.D. Lecturer of Pharmaceutics, Alexandria, Egypt. Interested in Formulation and Evaluation of Local Drug Delivery Systems for the Treatment of Periodontal Pockets.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2014
Sprache
Englisch
ISBN 10 
3659629782
ISBN 13 
9783659629785
Einband
Taschenbuch
Anzahl der Seiten
112
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Presses Academiques Francophones
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Brivibas gatve 197
Riga
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Lettland