Design and Synthesis of Gd(3+) Based MRI Contrast Agents - Softcover

Ur Rashid, Haroon

Softcover

ISBN 10: 3659632821 ISBN 13: 9783659632822

Verlag: LAP LAMBERT Academic Publishing, 2014

Inhaltsangabe

Magnetic Resonance Imaging (MRI) has become a prominent imaging technique in medicine.MRI contrast agents are used to increase the sensitivity of this technique.1,4,7,10-teraazacyclododecane (cyclen) is a key macrocycle used for the synthesis of Magnetic Resonance Imaging (MRI) contrast agents. Substituting the hydrogen atoms (attached to the nitrogen atoms in the ring) of cyclen with suitable groups produce stable ligands. These ligands on complexation with Ln3+ ions lead to the formation of useful chelates. Cyclen is widely synthesized via Richman and Atkins method.Recently, a new method for cancer treatment with a less side effect called photodynamic therapy (PDT) has been introduced. In this method cancer tissues are selectively destroyed without injuring the surrounding healthy cells. However, for the successful use of this method, the selection of an appropriate photosensitizer is important. Hence, it diagnosis-treat union of MRI and PDT will be significantly promoted if a new family of bi-functional agents is found, which would combine the effects of a contrast agent in MRI and of a photosensitizer in PDT. It will bring great improvement to the cancer diagnosis and treatment

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Über die Autorin bzw. den Autor

The author was born (1980) in Swabi, Pakistan.He graduated in Organic Chemistry from University of Peshawar,Pakistan in 2002.He earned his PhD (2012) in Synthetic Organic Chemistry from School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST) Wuhan, China under the superv-ision of Prof. Dr. Kaichao Yu.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2014
• Sprache: Englisch
• ISBN 10: 3659632821
• ISBN 13: 9783659632822
• Einband: Taschenbuch
• Anzahl der Seiten: 136
• Kontakt zum Hersteller: Nicht verfügbar
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