Floating Alginate Microbeads of Sumatriptan Succinate: Formulation, Development, Evaluation - Softcover

Jagdale, Swati; Patil, Satej

 
9783659633980: Floating Alginate Microbeads of Sumatriptan Succinate: Formulation, Development, Evaluation
Softcover
ISBN 10: 3659633984 ISBN 13: 9783659633980
Verlag: LAP LAMBERT Academic Publishing, 2014

Inhaltsangabe

Sumatriptan succinate is effective in ∼70% of migraine attacks but has short duration of action and low oral bio-availability due to first pass metabolism. It has elimination half-life of 2.5 hours and has absorption zone from stomach and upper part of small intestinal tract. In present study floating alginate microbeads system has been designed for gastro retention. Sodium alginate (low methoxy grade), HPMC K15M and Pluronic F127 were selected for preparation of microbeads of Sumatriptan succinate. Sumatriptan succinate loaded microbeads were prepared using ionotrophic gelation method. The effect of various process variables as Stirring Speed, Needle size, Dropping distance, Medium for gelation, Gelation time as well as formulation variables were studied. Prepared microbeads were evaluated for micromeritic properties, percentage microbeads yield, percent floating capacity, percent drug entrapment efficiency and percent drug release. In the present book Optimization of process variable and formulation variable of microbeads were carried out. The book will be useful for the researchers working in the areas of formulation development of Pharmaceuticals.

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Über die Autorin bzw. den Autor

Dr.Swati Jagdale M.Pharm, Ph.D, M.B.A; Studied at University of Pune. She is presently working as Professor and Head, Department of Pharmaceutics at MAEER's Maharashtra Institute of Pharmacy,MIT Campus, Kothrud, Pune, (MS), India.She has 14 years of academic experience. She has expertise in field of formulation development of Pharmaceutical

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2014
Sprache
Englisch
ISBN 10 
3659633984
ISBN 13 
9783659633980
Einband
Taschenbuch
Anzahl der Seiten
120
Kontakt zum Hersteller
Nicht verfügbar
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