Formulation & evaluation of delayed release anti depressant capsule - Softcover

Garg, Yogesh Kumar; Sharma, Gaurav Kumar; Yogi, Abhishek

Softcover

ISBN 10: 3659693898 ISBN 13: 9783659693892

Verlag: LAP LAMBERT Academic Publishing, 2015

Inhaltsangabe

The aim of work entitled "To Develop a Delayed release Capsule Formulation of Antidepressant Drug" was to formulate a stable as well as robust dosage form. The basic objective was to develop a Delayed Release Formulation of Antidepressant Drug. It is a generic version of Antidepressant capsules in line with the innovator. A generic version of Capsule was developed that is safe, efficacious and bioequivalent to the reference product. The compatibility parameters characterization of Antidepressant drug and excipients were done by chemical method and found interaction between Antidepressant drug and free acid present in enteric polymers hydroxypropyl methylcellulose phthalate, which forms phthalamide impurities under stress conditions .So the enteric layer must be separated from the drug layer by a barrier layer.The Antidepressant Drug was evaluated for bulk density, tapped density, Carr's index and Hausner's Ratio. It was found that the drug has good flow properties.The formulation of Delayed release pellets was done in Fluidized bed Processor(GPCG 1.1) in 3 steps. 1. Drug layering on Sugar spheres. 2. Barrier Coating on drug layered pellets. 3. Enteric Coating on pellets.

Über diesen Titel

Über die Autorin bzw. den Autor

Yogesh kumar garg,M.Pharma(Pharmaceutics);Rajasthan university of health sciences,Jaipur. Asst.professor at Shri Bajrang College Of Pharmacy, Bharatpur ,Rajasthan (India).

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2015
• Sprache: Englisch
• ISBN 10: 3659693898
• ISBN 13: 9783659693892
• Einband: Taschenbuch
• Anzahl der Seiten: 96
• Kontakt zum Hersteller: Nicht verfügbar
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