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Synthesis and Glycosidase Inhibitory Activity of Azasugars: Novel synthesis of piperidine- and pyrrolidine-homoazasugars, bicyclic diazasugars and isofagomines as enzyme inhibitors - Softcover

Matin, Mohammed Mahbubul

 
9783659850882: Synthesis and Glycosidase Inhibitory Activity of Azasugars: Novel synthesis of piperidine- and pyrrolidine-homoazasugars, bicyclic diazasugars and isofagomines as enzyme inhibitors
Softcover
ISBN 10: 3659850888 ISBN 13: 9783659850882
Verlag: LAP LAMBERT Academic Publishing, 2016

Inhaltsangabe

There is growing interest amongst scientific community in a heterogeneous group of hydrophilic plant alkaloids like polyhydroxylated monocyclic piperidine, pyrrolidine and bicyclic indolizidine, pyrrolizidine, quinolizidine and nortropane owing to their potential biological activities. These alkaloids have been given various generic names e.g. azasugars, iminosugars, polyhydroxy alkaloids, aminosugars etc. So, azasugars are polyhydroxylated alkaloids in which the endocyclic oxygen atom of the sugar ring is replaced with the basic nitrogen. Mere this atomic substitution confers these compounds with the ability to mimic sugars and inhibit various carbohydrate processing enzymes; most significantly the glycosidases (glycoside hydrolases) which are intimately involved in a huge array of biological functions. The present book described the natural occurrence of piperidine homoazasugars, pyrrolidine homoazasugars, bicyclic diazasugars and 1-azasugars. The synthetic aspects of these azasugars using a number of methodologies including chemo-enzymatic methods have discussed. The structural basis for the specificity of glycosidase inhibition and biological application is also described.

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Über die Autorin bzw. den Autor

Prof. Matin received his Ph.D. from the University of Pune, India and M.Sc. & B.Sc. (Honours) from the University of Chittagong, Bangladesh. He was the post-doctoral Fellow at Institute of Biological Sciences, Academia Sinica, Taiwan. He has a good teaching and research experience in the field of Organic, Bioorganic and Natural Product Chemistry.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2016
Sprache
Englisch
ISBN 10 
3659850888
ISBN 13 
9783659850882
Einband
Taschenbuch
Anzahl der Seiten
284
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
SIA OmniScriptum Publishing
customerservice@vdm-vsg.de

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