Synthesis & Characterization of Coumarin based antimalarial agents: Synthesis, Characterization & Molecular Modeling Studies of Coumarin based Falcipain-2 Inhibitors as Antimalarial agents - Softcover

Patel, Kuldeep Singh; Dhiman, Neerupma

 
9783659907463: Synthesis & Characterization of Coumarin based antimalarial agents: Synthesis, Characterization & Molecular Modeling Studies of Coumarin based Falcipain-2 Inhibitors as Antimalarial agents
Softcover
ISBN 10: 3659907464 ISBN 13: 9783659907463
Verlag: LAP LAMBERT Academic Publishing, 2017

Inhaltsangabe

Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill about two million people, mainly children, each year. Several new drugs along with chloroquine, the first synthetically developed antimalarial drug proved to be a successful cure in the past 50 years. The emergence and spread of resistant parasites to some of the drugs and their combination has made it virtually ineffective in most parts of the world. Few newer drugs like lumefantrine, Maloprim, Primaquine retain efficacy, have limitations and have a high cost. And thus, it is indispensable to discover, design, and develop new drugs with different mechanisms, with diversity in chemical structure and be efficacious against drug resistant strain. In addition to this it should be safe for small children and pregnant women, and be affordable. There are several targets validated for development of antimalarial agents. Falcipain-2 is a cysteine protease enzyme, a validated target for malaria. Several studies confirmed the efficacy of cysteine protease inhibitors in arresting and killing parasites in tissue culture models of parasite replication or cell invasion.

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Über die Autorin bzw. den Autor

Mr.Kuldeep Patel,M.Pharm,B.Pharm is an Associate Professor in NRI Institute of Pharmaceutical Science,Bhopal,India. He is pursuing Ph.d from AIP, Amity University NOIDA, U.P. He has 7 years teaching experience. He has published 14 International research papers & 9 National research papers. He has actively participated in many Conferences & Seminars

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2017
Sprache
Englisch
ISBN 10 
3659907464
ISBN 13 
9783659907463
Einband
Taschenbuch
Anzahl der Seiten
84
Kontakt zum Hersteller
preigu GmbH & Co. KG
mail@preigu.de

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