Highly selective OFF-ON fluorescent sensor for D-3-HB in aqueous - Softcover

Wang, Qingming

Softcover

ISBN 10: 3659953679 ISBN 13: 9783659953675

Verlag: LAP LAMBERT Academic Publishing, 2016

Inhaltsangabe

Diabetic ketoacidosis ( DKA ) is the most common hyper-glycemic emergency in patients with diabetes, and it was caused by too much ketones. Among the total ketone body, D-3-hydroxybutyric acid ( D-3-HB ) is the major, nearly 78%. So the detection of serum D-3-HB has been a routine marker for diagnosis of diabetic ketoacidosis. Fluorescent detection is the most efficient method, operational simplicity, low cost, real time monitoring and high sensitivity. Here, Two novel probe, 4-(2-hydroxybenzylicene)thiosemicarbazide ( 1 ) and 4-(1H- imidazo[4,5-f][1,10]- phenanthrolin-2-yl)phenol ( 2 ), were synthesized and shown a peculiar OFF-ON fluorescent response to D-3-HB in aqueous. The probe 1 & 2 have exhibited a selective and sensitive response to the D-3-HB over other common metal ions, anions and amino acids. Moreover the mechanism was confirmed by 1H-NMR and ESI-MS. Furthermore, this probe 1 successfully applied to bioimaging, demonstrating its value of practical applications in biological systems.

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Über die Autorin bzw. den Autor

Qingming Wang was born in Jiangsu,China, in 1984. He received his PhD in 2012 from Shanxi University. Subsequently he became an associate professor in Yancheng Teachers' University, China. His recent research focuses on the synthesis of optical probes based on fluorescein, coumarin, chromene, supramolecular chemistry and chiral molecules.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2016
• Sprache: Englisch
• ISBN 10: 3659953679
• ISBN 13: 9783659953675
• Einband: Taschenbuch
• Anzahl der Seiten: 56
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar