Highly selective OFF-ON fluorescent sensor for D-3-HB in aqueous - Softcover

Wang, Qingming

 
9783659953675: Highly selective OFF-ON fluorescent sensor for D-3-HB in aqueous
Softcover
ISBN 10: 3659953679 ISBN 13: 9783659953675
Verlag: LAP LAMBERT Academic Publishing, 2016

Inhaltsangabe

Diabetic ketoacidosis ( DKA ) is the most common hyper-glycemic emergency in patients with diabetes, and it was caused by too much ketones. Among the total ketone body, D-3-hydroxybutyric acid ( D-3-HB ) is the major, nearly 78%. So the detection of serum D-3-HB has been a routine marker for diagnosis of diabetic ketoacidosis. Fluorescent detection is the most efficient method, operational simplicity, low cost, real time monitoring and high sensitivity. Here, Two novel probe, 4-(2-hydroxybenzylicene)thiosemicarbazide ( 1 ) and 4-(1H- imidazo[4,5-f][1,10]- phenanthrolin-2-yl)phenol ( 2 ), were synthesized and shown a peculiar OFF-ON fluorescent response to D-3-HB in aqueous. The probe 1 & 2 have exhibited a selective and sensitive response to the D-3-HB over other common metal ions, anions and amino acids. Moreover the mechanism was confirmed by 1H-NMR and ESI-MS. Furthermore, this probe 1 successfully applied to bioimaging, demonstrating its value of practical applications in biological systems.

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Reseña del editor

Diabetic ketoacidosis ( DKA ) is the most common hyper-glycemic emergency in patients with diabetes, and it was caused by too much ketones. Among the total ketone body, D-3-hydroxybutyric acid ( D-3-HB ) is the major, nearly 78%. So the detection of serum D-3-HB has been a routine marker for diagnosis of diabetic ketoacidosis. Fluorescent detection is the most efficient method, operational simplicity, low cost, real time monitoring and high sensitivity. Here, Two novel probe, 4-(2-hydroxybenzylicene)thiosemicarbazide ( 1 ) and 4-(1H- imidazo[4,5-f][1,10]- phenanthrolin-2-yl)phenol ( 2 ), were synthesized and shown a peculiar OFF-ON fluorescent response to D-3-HB in aqueous. The probe 1 & 2 have exhibited a selective and sensitive response to the D-3-HB over other common metal ions, anions and amino acids. Moreover the mechanism was confirmed by 1H-NMR and ESI-MS. Furthermore, this probe 1 successfully applied to bioimaging, demonstrating its value of practical applications in biological systems.

Biografía del autor

Qingming Wang was born in Jiangsu,China, in 1984. He received his PhD in 2012 from Shanxi University. Subsequently he became an associate professor in Yancheng Teachers' University, China. His recent research focuses on the synthesis of optical probes based on fluorescein, coumarin, chromene, supramolecular chemistry and chiral molecules.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2016
Sprache
Englisch
ISBN 10 
3659953679
ISBN 13 
9783659953675
Einband
Tapa blanda
Anzahl der Seiten
56
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