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Airways Smooth Muscle: Vol 1 (Respiratory Pharmacology and Pharmacotherapy) - Hardcover

 
9783764350109: Airways Smooth Muscle: Vol 1 (Respiratory Pharmacology and Pharmacotherapy)

Inhaltsangabe

Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma- tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be- tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some- what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+- dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be increased (facilitation) or reduced (inhibition) by the action of a particular agent, thus changing the magnitude of the neurally-mediated response. Such agents would normally act on receptors on the nerve terminal which are referred to as pre-junctional (or presynaptic) receptors, in contrast to post-junctional (or post-synaptic) receptors located on the target cells which are influenced by that particular transmitter.

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Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma­ tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be­ tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some­ what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+­ dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be increased (facilitation) or reduced (inhibition) by the action of a particular agent, thus changing the magnitude of the neurally-mediated response. Such agents would normally act on receptors on the nerve terminal which are referred to as pre-junctional (or presynaptic) receptors, in contrast to post-junctional (or post-synaptic) receptors located on the target cells which are influenced by that particular transmitter.

Reseña del editor

The emphasis in this first volume in a series of research monographs is on the anatomical aspects of airways smooth muscle, including its innervation and neurotransmission. Scientists have contributed chapters on anatomy, gross morphology and ultrastrucure, sympathetic, parasympathetic and NANC innervation, vagal reflexes, prejunctional regulation of neurotransmission, and neural elements in airways smooth muscle. Containing reviews of the latest research data and developments in the field, this reference should provide a useful source of information for anatomists, physiologists, pharmacologists and developmental biologists, as well as clinicians.

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9783034875608: Airways Smooth Muscle: Structure, Innervation and Neurotransmission (Respiratory Pharmacology and Pharmacotherapy)

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ISBN 10:  3034875606 ISBN 13:  9783034875608
Verlag: Birkhäuser, 2012
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M. A. Giembycz et David Raeburn
Verlag: Birkhauser Verlag AG, 1994
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Hardcover. Zustand: Très bon. Ancien livre de bibliothèque. Edition 1994. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 1994. Ammareal gives back up to 15% of this item's net price to charity organizations. Bestandsnummer des Verkäufers E-435-343

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David Raeburn; Mark A. Giembycz
Verlag: Birkhäuser, Switzerland, 1994
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Hardcover. Zustand: Very Good. No Jacket. 9783764350109. Pictorial board hardcover, from closed Astra Zeneca company library. 332 pages, index, illustrated. Many factors may influence the release of neurotransmitters from airway nerves. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Contents clean, tight and bright. Book. Bestandsnummer des Verkäufers 030322

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