Prostaglandins and Control of Vascular Smooth Cell Proliferation: v. 48 (Agents and Actions, Supplements) - Hardcover

 
9783764356897: Prostaglandins and Control of Vascular Smooth Cell Proliferation: v. 48 (Agents and Actions, Supplements)
Hardcover
ISBN 10: 3764356898 ISBN 13: 9783764356897
Verlag: Birkhauser Verlag AG, 1997

Inhaltsangabe

Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth- modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.

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Reseña del editor

Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth­ modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.

Reseña del editor

Based on an International Conference held in Vienna, 1996, this volume contains contributions on several aspects of vascular smooth muscle function, phenotype expression and regulation of proliferation of vascular smooth muscle cell by prostaglandis or thromboxane.

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Verlag
Birkhauser Verlag AG
Erscheinungsdatum
1997
Sprache
Englisch
ISBN 10 
3764356898
ISBN 13 
9783764356897
Einband
Tapa dura
Anzahl der Seiten
136
Herausgeber
Schror Karsten, Nev P.
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Nicht verfügbar

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9783034873543: Prostaglandins and Control of Vascular Smooth Muscle Cell Proliferation: 48 (Agents and Actions Supplements)

Vorgestellte Ausgabe

ISBN 10:  3034873549 ISBN 13:  9783034873543
Verlag: Birkhäuser, 2012
Softcover