Oncogenes as Transcriptional Regulators: Cell Cycle Regulators and Chromosomal Translocation: v. 2 (Progress in Gene Expression) - Hardcover

Hardcover

ISBN 10: 3764357096 ISBN 13: 9783764357092

Verlag: Birkhäuser, 1997

Inhaltsangabe

1 E2Fs and the Retinoblastoma Protein Family.- 2 Signalling to the C-terminus of p53.- 3 Chromosome Translocations Generating Chimeric Transcription Factors, Unique Genetic Events with Pleiotropic Cellular Consequences.- 4 The Runt Domain Transcription Factor, PEBP2/CBF, and its Involvement in Human Leukemia.- 5 EBNA2: A Viral Transcription Factor Essential for the Immortalization of Human B Lymphocytes by the Epstein-Barr Virus (EBV).

Über diesen Titel

Reseña del editor

The study of molecular events leading to cellular transformation and cancer has progressed considerably during the 1990s. It has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic programme of the cell. Transcription factors can behave either as oncogenes or as tumor supressor genes. To date only a very limited number of transcription factors have been associated with cancer. This volume gives molecular information on several oncogenes, tumor suppressor genes or chromosomal translocations. Each chapter contains a description of the structure of such transcription factors, the nature of target genes, the regulation of their activities and an explaination of how they can deregulate cell growth and differentiation. This book should be suitable for the specialist scientist and the advanced student

Details zur Ausgabe

• Verlag: Birkhäuser
• Erscheinungsdatum: 1997
• Sprache: Englisch
• ISBN 10: 3764357096
• ISBN 13: 9783764357092
• Einband: Tapa dura
• Anzahl der Seiten: 180
• Herausgeber: Yaniv Moshe, Ghysdael Jacques
• Kontakt zum Hersteller: Nicht verfügbar