List of Contents.- Section 1 - Epidemiology and environment.- Schizophrenia and migration.- Childhood meningitis and adult schizophrenia.- The course and outcome of schizophrenia: toward a new social biology of psychosis.- Psychotic features in the general population.Risk factors for what?.- Discussion: Epidemiology and environment.- Section 2 - Precursors of schizophrenia.- Early developmental abnormalities - risk for what?.- Are there specific risk factors for schizophrenia?.- Risk factors for schizophrenia in adolescents.- Cannabis as a causal factor for psychosis - a review of the evidence.- Discussion: Schizophrenia - diverse etiologies,common pathogenesis.- Section 3 - Pathophysiological mechanisms.- Genetic liability, brain structure and symptoms of schizophrenia.- The hippocampus and schizophrenia.- Neuroimaging studies of auditory verbal hallucinations.- Gender differences in schizophrenia.- Section 4 - Genetics.- Searching for inherited causes for schizophrenia:has progress been made?.- Gene expression in psychotic disorders:dissecting the genetic basis of complex neuropsychiatric disorders.- Brain morphological abnormalities in first-degree relatives of schizophrenic patients.- Genetics of schizophrenia and the impact of neuropsychology.- Human genome and the perspectives for schizophrenia.- Discussion: The genetics of psychosis is the genetics of the speciation of Homo sapiens.- Section 5 - Controversies in schizophrenia.- Criminal and antisocial behaviours and schizophrenia: a neglected topic.- The aetiological continuum of psychosis.- When does structural brain change appear in schizophrenia and is it clinically relevant?.- Schizophrenia: developmental, degenerative or both?.- Schizophrenia as a progressive developmental disorder:the evidence and its implications.- Controversies in schizophrenia research:the ’continuum’ challenge, heterogeneity vs homogeneity, and lifetime developmental-’neuroprogressive’ trajectory.- Section 6 - Treatment.- What can psychological treatments say about causes in schizophrenia?.- Intervention in the prepsychotic phase of schizophrenia and related disorders: towards effective and safe strategies for earliest intervention in psychotic disorders.- What can molecular imaging tell us about schizophrenia?.- Schizophrenia: treatment issues in the 21stcentury.
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This book comprises the conferences and discussions presented at the 5th Symposium on the "Search for the Causes of Schizophrenia", which took place for the second time in Guaruja, Brazil, April 2003. This series of symposia started in 1986, on the occasion of the 600th anniversary of the University of Heidelberg, Germany, followed by symposia in 1989, 1993 and 1998. Four volumes that have been widely used as a reference for comprehensive reviews on the state of the art in schizophrenia research have resulted from these meetings. They reflect the progress resulting from the most relevant studies on the etiology of the disease. The topics covered in the six sections of the book are Epidemiology and Environment, Precursors, Pathophysiological Mechanisms, Genetics, Controversies in Schizophrenia, and Treatment.
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