Oscillations occur in many different biological processes, for example as circadian oscillations, in the canonical NF- sciptsize KB-pathway, and calcium signaling. The oscillations can differ in the intensity of their response towards perturbations, the so-called robustness or sensitivity of the particular response. Thereby, the period of calcium oscillations whose function is discussed to lie in frequency encoded signal transduction is known to be very sensitive. Contrariwise, the period of circadian rhythms is very robust; it has to remain nearly unaffected by changes of temperature, pH and nutritional conditions in order to provide reliable timing. A priori, the origins of these differences in period sensitivities are widely unknown. This thesis deals with the effect of system characteristics such as feedback, matter flow properties and kinetics on the period and amplitude sensitivities of oscillating systems. Taking a computational approach, ordinary differential equation models of prototype oscillators are examined for which parameter sets are sampled and sensitivity coeffcients for perturbations of the kinetic parameters are calculated. The detailed analysis shows that besides the feedback type, also matter flow properties and kinetics yield a strong influence on the observed period and amplitude sensitivities. The validity of the results obtained for the prototype oscillators is furthermore examined for published models of calcium and circadian oscillations, and the effect of saturating kinetics is confirmed for models of synthetic oscillators.
Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.
Anbieter: ISD LLC, Bristol, CT, USA
paperback. Zustand: New. Bestandsnummer des Verkäufers 557241
Anbieter: GreatBookPrices, Columbia, MD, USA
Zustand: New. Bestandsnummer des Verkäufers 45932708-n
Anbieter: Grand Eagle Retail, Bensenville, IL, USA
Paperback. Zustand: new. Paperback. Oscillations occur in many different biological processes, for example as circadian oscillations, in the canonical NF- sciptsize KB-pathway, and calcium signaling. The oscillations can differ in the intensity of their response towards perturbations, the so-called robustness or sensitivity of the particular response. Thereby, the period of calcium oscillations whose function is discussed to lie in frequency encoded signal transduction is known to be very sensitive. Contrariwise, the period of circadian rhythms is very robust; it has to remain nearly unaffected by changes of temperature, pH and nutritional conditions in order to provide reliable timing. A priori, the origins of these differences in period sensitivities are widely unknown. This thesis deals with the effect of system characteristics such as feedback, matter flow properties and kinetics on the period and amplitude sensitivities of oscillating systems. Taking a computational approach, ordinary differential equation models of prototype oscillators are examined for which parameter sets are sampled and sensitivity coeffcients for perturbations of the kinetic parameters are calculated.The detailed analysis shows that besides the feedback type, also matter flow properties and kinetics yield a strong influence on the observed period and amplitude sensitivities. The validity of the results obtained for the prototype oscillators is furthermore examined for published models of calcium and circadian oscillations, and the effect of saturating kinetics is confirmed for models of synthetic oscillators. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Bestandsnummer des Verkäufers 9783832538316
Anbieter: GreatBookPrices, Columbia, MD, USA
Zustand: As New. Unread book in perfect condition. Bestandsnummer des Verkäufers 45932708
Anbieter: Kennys Bookstore, Olney, MD, USA
Zustand: New. 2014. Paperback. . . . . . Books ship from the US and Ireland. Bestandsnummer des Verkäufers V9783832538316
Anbieter: AussieBookSeller, Truganina, VIC, Australien
Paperback. Zustand: new. Paperback. Oscillations occur in many different biological processes, for example as circadian oscillations, in the canonical NF- sciptsize KB-pathway, and calcium signaling. The oscillations can differ in the intensity of their response towards perturbations, the so-called robustness or sensitivity of the particular response. Thereby, the period of calcium oscillations whose function is discussed to lie in frequency encoded signal transduction is known to be very sensitive. Contrariwise, the period of circadian rhythms is very robust; it has to remain nearly unaffected by changes of temperature, pH and nutritional conditions in order to provide reliable timing. A priori, the origins of these differences in period sensitivities are widely unknown. This thesis deals with the effect of system characteristics such as feedback, matter flow properties and kinetics on the period and amplitude sensitivities of oscillating systems. Taking a computational approach, ordinary differential equation models of prototype oscillators are examined for which parameter sets are sampled and sensitivity coeffcients for perturbations of the kinetic parameters are calculated.The detailed analysis shows that besides the feedback type, also matter flow properties and kinetics yield a strong influence on the observed period and amplitude sensitivities. The validity of the results obtained for the prototype oscillators is furthermore examined for published models of calcium and circadian oscillations, and the effect of saturating kinetics is confirmed for models of synthetic oscillators. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Bestandsnummer des Verkäufers 9783832538316
Anzahl: 1 verfügbar
Anbieter: Kennys Bookshop and Art Galleries Ltd., Galway, GY, Irland
Zustand: New. 2014. Paperback. . . . . . Bestandsnummer des Verkäufers V9783832538316