Explicit solvent effects on protein physics: Modeling lattice proteins in aqueous environments - Softcover

Salvi, Giovanni

Softcover

ISBN 10: 3838107713 ISBN 13: 9783838107714

Verlag: Südwestdeutscher Verlag für Hochschulschriften, 2009

Inhaltsangabe

Protein folding stands as one of the major interdisciplinary challenges of the last fifteen years, involving biology, chemistry, medicine and physics. In this book solvent effects, and the related hydrophobic effect, on proteins are investigated. Using a simple lattice model of proteins, in which the solvent is semi-explicitly taken into account, thermodynamical quantities can be investigated and the crucial role the solvent plays in protein folding can be demonstrated. Of particular relevance is our observation that a simple model, in which the potential energy is described in terms of the interactions between amino-acids only, does not correctly reproduce solvent effects. Approaches like this, in which solvent effects are treated implicitly, are commonly employed in many of more sophisticated models for protein folding dynamics. Our results are then of great importance as they suggest the treatment of the solvent in these models may need to be re-examined.

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Über die Autorin bzw. den Autor

Giovanni Salvi received an M.S. degree in Physics from theUniversity of Lausanne, Switzerland, in 2000 and a Ph.D. degreefrom EPF Lausanne, in 2004. He then worked for two years at SeoulNational University in Seoul, South Korea. He is currentlyworking as a researcher at ETH Zürich on using Molecular Dynamicsto study proteins.

Details zur Ausgabe

• Verlag: Südwestdeutscher Verlag für Hochschulschriften
• Erscheinungsdatum: 2009
• Sprache: Englisch
• ISBN 10: 3838107713
• ISBN 13: 9783838107714
• Einband: Taschenbuch
• Anzahl der Seiten: 108
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar