Epigenetics in cancer: Genome-wide analysis of aberrant CpG island methylation in human tumors

0 durchschnittliche Bewertung
( 0 Bewertungen bei Goodreads )
 
9783838120706: Epigenetics in cancer: Genome-wide analysis of aberrant CpG island methylation in human tumors

Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

About the Author:

Claudia Gebhard was born in Oberviechtach (Bavaria, Germany). From 1999-2005 she studied molecular biology at the University of Regensburg (Germany). In 2010 she received her Ph.D. degree in the Department of Hematology and Oncology at the University Hospital of Regensburg where she is now working as a postdoc.

„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.

Beste Suchergebnisse bei AbeBooks

1.

Gebhard, Claudia
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu Anzahl: 1
Anbieter
European-Media-Service Mannheim
(Mannheim, Deutschland)
Bewertung
[?]

Buchbeschreibung Buchzustand: New. Publisher/Verlag: Südwestdeutscher Verlag für Hochschulschriften | Genome-wide analysis of aberrant CpG island methylation in human tumors | Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer. | Format: Paperback | Language/Sprache: english | 196 pp. Buchnummer des Verkäufers K9783838120706

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 74,08
Währung umrechnen

In den Warenkorb

Versand: EUR 2,99
Von Deutschland nach USA
Versandziele, Kosten & Dauer

2.

Claudia Gebhard
Verlag: Sudwestdeutscher Verlag Fur Hochschulschriften AG 2010-11-16 (2010)
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu paperback Anzahl: > 20
Anbieter
Blackwell's
(Oxford, OX, Vereinigtes Königreich)
Bewertung
[?]

Buchbeschreibung Sudwestdeutscher Verlag Fur Hochschulschriften AG 2010-11-16, 2010. paperback. Buchzustand: New. Buchnummer des Verkäufers 9783838120706

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 72,82
Währung umrechnen

In den Warenkorb

Versand: EUR 6,71
Von Vereinigtes Königreich nach USA
Versandziele, Kosten & Dauer

3.

Claudia Gebhard
Verlag: Sudwestdeutscher Verlag Fur Hochschulschriften AG (2010)
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu Anzahl: > 20
Print-on-Demand
Anbieter
Books2Anywhere
(Fairford, GLOS, Vereinigtes Königreich)
Bewertung
[?]

Buchbeschreibung Sudwestdeutscher Verlag Fur Hochschulschriften AG, 2010. PAP. Buchzustand: New. New Book. Delivered from our UK warehouse in 3 to 5 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Buchnummer des Verkäufers LQ-9783838120706

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 83,14
Währung umrechnen

In den Warenkorb

Versand: EUR 10,06
Von Vereinigtes Königreich nach USA
Versandziele, Kosten & Dauer

4.

Gebhard, Claudia
Verlag: Südwestdeutscher Verlag für Hochschulschriften (2016)
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu Paperback Anzahl: 1
Print-on-Demand
Anbieter
Ria Christie Collections
(Uxbridge, Vereinigtes Königreich)
Bewertung
[?]

Buchbeschreibung Südwestdeutscher Verlag für Hochschulschriften, 2016. Paperback. Buchzustand: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Buchnummer des Verkäufers ria9783838120706_lsuk

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 89,82
Währung umrechnen

In den Warenkorb

Versand: EUR 4,34
Von Vereinigtes Königreich nach USA
Versandziele, Kosten & Dauer

5.

Claudia Gebhard
Verlag: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Nov 2015 (2015)
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu Taschenbuch Anzahl: 2
Anbieter
Rheinberg-Buch
(Bergisch Gladbach, Deutschland)
Bewertung
[?]

Buchbeschreibung Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Nov 2015, 2015. Taschenbuch. Buchzustand: Neu. Neuware - Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer. 196 pp. Englisch. Buchnummer des Verkäufers 9783838120706

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 79,90
Währung umrechnen

In den Warenkorb

Versand: EUR 17,13
Von Deutschland nach USA
Versandziele, Kosten & Dauer

6.

Claudia Gebhard
Verlag: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Nov 2015 (2015)
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu Taschenbuch Anzahl: 2
Anbieter
BuchWeltWeit Inh. Ludwig Meier e.K.
(Bergisch Gladbach, Deutschland)
Bewertung
[?]

Buchbeschreibung Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Nov 2015, 2015. Taschenbuch. Buchzustand: Neu. Neuware - Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer. 196 pp. Englisch. Buchnummer des Verkäufers 9783838120706

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 79,90
Währung umrechnen

In den Warenkorb

Versand: EUR 17,13
Von Deutschland nach USA
Versandziele, Kosten & Dauer

7.

Claudia Gebhard
Verlag: Sudwestdeutscher Verlag Fur Hochschulschriften AG (2010)
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu Anzahl: > 20
Print-on-Demand
Anbieter
Pbshop
(Wood Dale, IL, USA)
Bewertung
[?]

Buchbeschreibung Sudwestdeutscher Verlag Fur Hochschulschriften AG, 2010. PAP. Buchzustand: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Buchnummer des Verkäufers IQ-9783838120706

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 97,82
Währung umrechnen

In den Warenkorb

Versand: EUR 3,34
Innerhalb USA
Versandziele, Kosten & Dauer

8.

Claudia Gebhard
Verlag: Sudwestdeutscher Verlag Fur Hochschulschriften AG, United States (2015)
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu Paperback Anzahl: 1
Anbieter
The Book Depository EURO
(London, Vereinigtes Königreich)
Bewertung
[?]

Buchbeschreibung Sudwestdeutscher Verlag Fur Hochschulschriften AG, United States, 2015. Paperback. Buchzustand: New. Language: English . Brand New Book. Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer. Buchnummer des Verkäufers KNV9783838120706

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 119,85
Währung umrechnen

In den Warenkorb

Versand: EUR 3,36
Von Vereinigtes Königreich nach USA
Versandziele, Kosten & Dauer

9.

Claudia Gebhard
Verlag: Sudwestdeutscher Verlag Fur Hochschulschriften AG
ISBN 10: 3838120701 ISBN 13: 9783838120706
Neu Paperback Anzahl: > 20
Anbieter
BuySomeBooks
(Las Vegas, NV, USA)
Bewertung
[?]

Buchbeschreibung Sudwestdeutscher Verlag Fur Hochschulschriften AG. Paperback. Buchzustand: New. Paperback. 196 pages. Dimensions: 8.7in. x 5.9in. x 0.5in.Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Buchnummer des Verkäufers 9783838120706

Weitere Informationen zu diesem Verkäufer | Frage an den Anbieter

Neu kaufen
EUR 150,16
Währung umrechnen

In den Warenkorb

Versand: Gratis
Innerhalb USA
Versandziele, Kosten & Dauer