Epigenetics in cancer: Genome-wide analysis of aberrant CpG island methylation in human tumors - Softcover

Gebhard, Claudia

Softcover

ISBN 10: 3838120701 ISBN 13: 9783838120706

Verlag: Südwestdeutscher Verlag für Hochschulschriften, 2010

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Reseña del editor:

Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer.

Biografía del autor:

Claudia Gebhard was born in Oberviechtach (Bavaria, Germany). From 1999-2005 she studied molecular biology at the University of Regensburg (Germany). In 2010 she received her Ph.D. degree in the Department of Hematology and Oncology at the University Hospital of Regensburg where she is now working as a postdoc.

Über diese Auflage

• Verlag: Südwestdeutscher Verlag für Hochschulschriften
• Erscheinungsdatum: 2010
• ISBN 10: 3838120701
• ISBN 13: 9783838120706
• Einband: Tapa blanda
• Anzahl der Seiten: 196