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Quantifying cell-ECM adhesion by single cell force spectroscopy: Quantifying adhesive interactions between cells and extracellular matrix by atomic ... based single cell force spectroscopy - Softcover

Taubenberger, Anna

 
9783838124278: Quantifying cell-ECM adhesion by single cell force spectroscopy: Quantifying adhesive interactions between cells and extracellular matrix by atomic ... based single cell force spectroscopy
Softcover
ISBN 10: 3838124278 ISBN 13: 9783838124278
Verlag: Suedwestdeutscher Verlag fuer Hochschulschriften, 2011

Inhaltsangabe

Integrin-mediated adhesive interactions of cells with the extracellular matrix (ECM) regulate important cellular functions and play a critical role in disease. Therefore, studying the mechanisms underlying integrin-binding and regulation is of great interest. In the presented work three respective biological questions have been addressed using Atomic Force Microscopy based Single Cell Force Spectroscopy (AFM-SCFS). The work is split into six chapters. The first chapter provides an introduction into cell-ECM interactions. Thereafter different adhesion assays are compared and contrasted, and the theoretical Bell-Evans model is discussed. In chapter four, alpha2beta1-integrin mediated cell adhesion to collagen I is quantified. Thereafter the effects of the exposure of cryptic integrin binding sites within collagen I on pre-osteoblasts are analysed. At last, the role of BCR/ABL in modulating myeloid progenitor cell adhesion to stromal cells and ECM-coated substrates is studied. Taken together, the work demonstrates that AFM-SCFS is a versatile tool that permits monitoring of cell adhesion from single-molecule recognition events to the formation of more complex adhesion sites.

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Über die Autorin bzw. den Autor

Anna Taubenberger, born 1980 in Kulmbach, Germany, graduated 2004 from the TU Dresden with a degree in Engineering. Between 2005 and 2009 she did her PhD at the Biotechnological Centre Dresden on the presented work. Since 2009 she is working as a DFG postdoctoral research fellow at Queensland University of Technology in Brisbane, Australia.

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Verlag
Suedwestdeutscher Verlag fuer Hochschulschriften
Erscheinungsdatum
2011
Sprache
Englisch
ISBN 10 
3838124278
ISBN 13 
9783838124278
Einband
Taschenbuch
Anzahl der Seiten
184
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Editions Muse
customerservice@vdm-vsg.de

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