Small non-coding RNAs in Prokaryotes: Roles in Pathogenesis and Potential Therapeutic Targets - Softcover

Ramos, Christian G.; M., André; H., Jorge

Softcover

ISBN 10: 3838321162 ISBN 13: 9783838321165

Verlag: LAP Lambert Academic Publishing, 2010

Inhaltsangabe

More than 140 bacterial small non-coding RNAs (sRNAs) have been discovered in Escherichia coli and other bacteria, most of them pathogenic. The sRNA genes are typically encoded in intergenic regions and range from 50 to 500 nucleotides long. Evidences accumulated over the last years point out that sRNAs act as major regulators of adaptive responses at the post-transcriptional level. The mechanisms by which sRNAs modulate the expression of its targets often involve the interaction with their mRNA targets, mediated by the Hfq protein a RNA chaperone. The RNA chaperone Hfq, has been shown to play multiple roles in the biology of bacteria, acting as a pleiotropic regulator. In recent years, the vast majority of sRNAs have been identified by bioinformatics, as is the case of the 213 putative sRNA genes in B. cenocepacia J2315. Preliminary identification and target prediction of Hfq-dependent sRNAs raise interesting questions. The roles played by sRNAs in gene regulation, their interdependence of Hfq and their potential as suitable targets for the development of new antimicrobials is presented and discussed.

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Über die Autorin bzw. den Autor

Christian Gomes Ramos is a PhD student at Instituto Superior Técnico, Universidade Técnica de Lisboa, Portugal. His research is focused on the identification and characterization of small non coding RNAs from bacteria of the Burkholderia cepacia complex. C.G. Ramos is co-author of 8 papers in international peer-reviewed journals.

Details zur Ausgabe

• Verlag: LAP Lambert Academic Publishing
• Erscheinungsdatum: 2010
• Sprache: Englisch
• ISBN 10: 3838321162
• ISBN 13: 9783838321165
• Einband: Taschenbuch
• Anzahl der Seiten: 84
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Presses Academiques Francophones; customerservice@vdm-vsg.de; ; Brivibas gatve 197; Riga; 1039; Lettland