Cell migration plays a vital role in many physiological processes, such as embryonic development and immunological defense, but also in pathological processes, such as tumor cell invasion. Amphoterin, also known as High-Mobility Group-Box protein 1 (HMGB1), is highly expressed in immature and malignant cells. Although it lacks a classical secretion signal, amphoterin is released from cells to regulate neurite outgrowth, cell migration and differentiation. Many extracellular functions of amphoterin are mediated by one of its cell surface receptors Receptor for Advanced Glycation End products (RAGE), a multiligand receptor belonging to the immunoglobulin superfamily. This thesis concentrates on identifying molecular mechanisms through which RAGE mediates effects of extracellular amphoterin on cells. The results suggest that amphoterin and RAGE serve as a ligand-receptor pair having important roles in the regulation of neuronal process growth, survival and differentiation, and in the regulation of tumor cell invasiveness.
Henri Huttunen earned his Ph.D. in biochemistry from University of Helsinki. His research focuses in molecular mechanisms underlying the generation and loss of connectivity of neurons in the brain. He has studied molecules regulating cell migration in the developing brain and more recently mechanisms of neurodegeneration in Alzheimer's disease.
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cell migration plays a vital role in many physiological processes, such as embryonic development and immunological defense, but also in pathological processes, such as tumor cell invasion. Amphoterin, also known as High-Mobility Group-Box protein 1 (HMGB1), is highly expressed in immature and malignant cells. Although it lacks a classical secretion signal, amphoterin is released from cells to regulate neurite outgrowth, cell migration and differentiation. Many extracellular functions of amphoterin are mediated by one of its cell surface receptors Receptor for Advanced Glycation End products (RAGE), a multiligand receptor belonging to the immunoglobulin superfamily. This thesis concentrates on identifying molecular mechanisms through which RAGE mediates effects of extracellular amphoterin on cells. The results suggest that amphoterin and RAGE serve as a ligand-receptor pair having important roles in the regulation of neuronal process growth, survival and differentiation, and in the regulation of tumor cell invasiveness. 64 pp. Englisch. Bestandsnummer des Verkäufers 9783838323473
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Cell migration plays a vital role in many physiological processes, such as embryonic development and immunological defense, but also in pathological processes, such as tumor cell invasion. Amphoterin, also known as High-Mobility Group-Box protein 1 (HMGB1), is highly expressed in immature and malignant cells. Although it lacks a classical secretion signal, amphoterin is released from cells to regulate neurite outgrowth, cell migration and differentiation. Many extracellular functions of amphoterin are mediated by one of its cell surface receptors Receptor for Advanced Glycation End products (RAGE), a multiligand receptor belonging to the immunoglobulin superfamily. This thesis concentrates on identifying molecular mechanisms through which RAGE mediates effects of extracellular amphoterin on cells. The results suggest that amphoterin and RAGE serve as a ligand-receptor pair having important roles in the regulation of neuronal process growth, survival and differentiation, and in the regulation of tumor cell invasiveness. Bestandsnummer des Verkäufers 9783838323473
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Huttunen HenriHenri Huttunen earned his Ph.D. in biochemistry from University of Helsinki. His research focuses in molecular mechanisms underlying the generation and loss of connectivity of neurons in the brain. He has studied mole. Bestandsnummer des Verkäufers 5413001
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Paperback. Zustand: Brand New. 64 pages. 8.70x5.94x0.31 inches. In Stock. Bestandsnummer des Verkäufers __3838323475
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Paperback. Zustand: Brand New. 64 pages. 8.70x5.94x0.31 inches. In Stock. Bestandsnummer des Verkäufers 3838323475
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