Modeling and Optimization of Protein Expression: Statistical Methods and Metabolic Flux Analysis for Optimization of Recombinant Protein Production by Fungal Platforms - Softcover

Gheshlaghi, Reza

 
9783838324395: Modeling and Optimization of Protein Expression: Statistical Methods and Metabolic Flux Analysis for Optimization of Recombinant Protein Production by Fungal Platforms
Softcover
ISBN 10: 3838324390 ISBN 13: 9783838324395
Verlag: LAP Lambert Academic Publishing, 2009

Inhaltsangabe

Scientific methods of enhancing gene expression including genomics, applied molecular biology, metabolic engineering, and combinatorial biosynthesis have been sufficiently developed to make a major impact on recombinant protein production. However, it appears that the combination of trial-and-error experimentation and molecular biology are not sufficient to design an optimum strategy to reach the goal. This book provides a thorough coverage of theoretical and design aspects of two engineering methodologies to overcome this shortcoming. Special emphasis was placed on the effect of the fermentation medium components of A.niger on a recombinant protein production. Statistically based experimental designs in a sequential manner were introduced as powerful tools and applied for medium optimization. A detailed metabolic network comprising intracellular compartments, amino acid catabolism and experimental flux measurements of the key metabolites should be developed and used for optimization purposes. The proposed strategy should be useful to professionals in the field of biotechnology who seek to understand the response of microorganisms to environmental stimuli.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

Über die Autorin bzw. den Autor

"Reza Gheshlaghi: Assistant Professor, Department of Chemical Engineering, Ferdowsi University of Mashhad, Iran" "Jeno Scharer: Professor,University of Waterloo, Canada,ON" "Murray Moo-Young: Professor,University of Waterloo, Canada,ON", "Ali Elkamel:Professor,University of Waterloo, Canada, ON"

„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.

Verlag
LAP Lambert Academic Publishing
Erscheinungsdatum
2009
Sprache
Englisch
ISBN 10 
3838324390
ISBN 13 
9783838324395
Einband
Taschenbuch
Anzahl der Seiten
180
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Nicht verfügbar