Computational Approaches: A worm case study - Softcover

Mahdavi, Mahmood A.; Lin, Yen-Han

Softcover

ISBN 10: 383832630X ISBN 13: 9783838326306

Verlag: LAP LAMBERT Academic Publishing, 2010

Inhaltsangabe

Systems biology seeks to integrate high-throughput biological studies to understand how biological systems function, by studying the relationships and interactions between various parts of a biological system. The metabolic networks, as a systemic cellular organization, can be reconstructed based on genomic information. The center- piece of this information is protein-protein interaction map of the studied organism. Signature content of proteins was utilized to reveal protein interactions upon a notion that when two proteins share signature in their primary structures, the two proteins are more likely to interact. Protein interaction methods often predict true positive interactions along with numerous false positive interactions. A global algorithm was also proposed to reduce the number of false positives. The predicted interactions were incorporated into the metabolic network of C. elegans, resulting in new interactions among metabolic pathways. This case study of integrating genomic information with biochemical knowledge helps biologists to improve the extent of their understanding of biological networks using huge genomic information

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Über die Autorinnen und Autoren

"Mahmood A. Mahdavi, Assistant professor, Department of Chemical Engineering, Ferdowsi University of Mashhad, Mashhad, 9177948974, Iran."

"Mahmood A. Mahdavi, Assistant professor, Department of Chemical Engineering, Ferdowsi University of Mashhad, Mashhad, 9177948974, Iran."

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2010
• Sprache: Englisch
• ISBN 10: 383832630X
• ISBN 13: 9783838326306
• Einband: Taschenbuch
• Anzahl der Seiten: 140
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: GPSR Kontakt; info@bod.de; ; Überseering 33; Hamburg; 22297; Deutschland