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THE FUNCTION OF MRN COMPLEX DURING WRN FACILITATED ATM ACTIVATION: THE FUNCTION OF MRN (MRE11-RAD50-NBS1) COMPLEX DURING WRN (WERNER) FACILITATED ATM (ATAXIA-TELANGIECTASIA MUTATED) ACTIVATION - Softcover
Inhaltsangabe
WRN (Werner) protein is a member of the RecQ family showing helicase and exonuclease activity. WRN protein may lose function upon mutation and causes Werner syndrome (WS) which is a cancer-prone and premature aging disease. ATM (Ataxia-Telangiectasia mutated) protein initiates a signaling pathway in response to DNA double strand breaks (DSBs). Genomic disorder ataxia-telangiectasia (A-T) is associated with defective ATM. WRN protein is involved in ATM pathway activation when cells are exposed to DSBs associated with replication fork collapse. Because the Mre11-Rad50-Nbs1 (MRN) complex, a sensor of DSBs, is known to interact with WRN and ATM, we investigated whether the MRN complex mediates the WRN-dependent ATM pathway activation. In this study, we employed short-hairpin RNA to generate WRN- and Nbs1-deficient U-2 OS (osteosarcoma) cells. Cells were treated with clastogens which induce collapsed replication forks, thus provided proof for whether WRN facilitates ATM activation via MRN complex. This study serves as a basis for future investigation on the correlation between ATM, MRN complex and WRN, which will help understand the mechanism of aging and cancer.
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Über die Autorin bzw. den Autor
Born in Shanghai, China, he got his BS degree of Biology in Fudan University. He then worked on transgenic plants in the Chinese University of Hong Kong and got his first MS degree there. After working for three years as a patent engineer, he went on doing research on cancer in the University of Maryland, College Park and got his second MS degree.
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THE FUNCTION OF MRN COMPLEX DURING WRN FACILITATED ATM ACTIVATION
Verlag:
LAP LAMBERT Academic Publishing Mrz 2010, 2010
ISBN 10: 3838353617
ISBN 13: 9783838353616
Neu
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Anbieter: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Deutschland
Verkäuferbewertung 5 von 5 Sternen
Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -WRN (Werner) protein is a member of the RecQ family showing helicase and exonuclease activity. WRN protein may lose function upon mutation and causes Werner syndrome (WS) which is a cancer-prone and premature aging disease. ATM (Ataxia-Telangiectasia mutated) protein initiates a signaling pathway in response to DNA double strand breaks (DSBs). Genomic disorder ataxia-telangiectasia (A-T) is associated with defective ATM. WRN protein is involved in ATM pathway activation when cells are exposed to DSBs associated with replication fork collapse. Because the Mre11-Rad50-Nbs1 (MRN) complex, a sensor of DSBs, is known to interact with WRN and ATM, we investigated whether the MRN complex mediates the WRN-dependent ATM pathway activation. In this study, we employed short-hairpin RNA to generate WRN- and Nbs1-deficient U-2 OS (osteosarcoma) cells. Cells were treated with clastogens which induce collapsed replication forks, thus provided proof for whether WRN facilitates ATM activation via MRN complex. This study serves as a basis for future investigation on the correlation between ATM, MRN complex and WRN, which will help understand the mechanism of aging and cancer. 76 pp. Englisch. Bestandsnummer des Verkäufers 9783838353616
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The Function of Mrn Complex During Wrn Facilitated ATM Activation
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
ISBN 10: 3838353617
ISBN 13: 9783838353616
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THE FUNCTION OF MRN COMPLEX DURING WRN FACILITATED ATM ACTIVATION : THE FUNCTION OF MRN (MRE11-RAD50-NBS1) COMPLEX DURING WRN (WERNER) FACILITATED ATM (ATAXIA-TELANGIECTASIA MUTATED) ACTIVATION
Verlag:
LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3838353617
ISBN 13: 9783838353616
Neu
Taschenbuch
Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland
Verkäuferbewertung 5 von 5 Sternen
Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - WRN (Werner) protein is a member of the RecQ family showing helicase and exonuclease activity. WRN protein may lose function upon mutation and causes Werner syndrome (WS) which is a cancer-prone and premature aging disease. ATM (Ataxia-Telangiectasia mutated) protein initiates a signaling pathway in response to DNA double strand breaks (DSBs). Genomic disorder ataxia-telangiectasia (A-T) is associated with defective ATM. WRN protein is involved in ATM pathway activation when cells are exposed to DSBs associated with replication fork collapse. Because the Mre11-Rad50-Nbs1 (MRN) complex, a sensor of DSBs, is known to interact with WRN and ATM, we investigated whether the MRN complex mediates the WRN-dependent ATM pathway activation. In this study, we employed short-hairpin RNA to generate WRN- and Nbs1-deficient U-2 OS (osteosarcoma) cells. Cells were treated with clastogens which induce collapsed replication forks, thus provided proof for whether WRN facilitates ATM activation via MRN complex. This study serves as a basis for future investigation on the correlation between ATM, MRN complex and WRN, which will help understand the mechanism of aging and cancer. Bestandsnummer des Verkäufers 9783838353616
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The Function of Mrn Complex During Wrn Facilitated ATM Activation
Verlag:
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
ISBN 10: 3838353617
ISBN 13: 9783838353616
Neu
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Anbieter: Majestic Books, Hounslow, Vereinigtes Königreich
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Zustand: New. Print on Demand pp. 76 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam. Bestandsnummer des Verkäufers 131776803
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The Function of Mrn Complex During Wrn Facilitated ATM Activation
Verlag:
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
ISBN 10: 3838353617
ISBN 13: 9783838353616
Neu
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Anbieter: Biblios, Frankfurt am main, HESSE, Deutschland
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Zustand: New. PRINT ON DEMAND pp. 76. Bestandsnummer des Verkäufers 18128810742
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THE FUNCTION OF MRN COMPLEX DURING WRN FACILITATED ATM ACTIVATION
Verlag:
LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3838353617
ISBN 13: 9783838353616
Neu
Softcover
Anbieter: moluna, Greven, Deutschland
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Ma JunhaoBorn in Shanghai, China, he got his BS degree of Biology in Fudan University. He then worked on transgenic plants in the Chinese University of Hong Kong and got his first MS degree there. After working for three years as a p. Bestandsnummer des Verkäufers 5415767
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THE FUNCTION OF MRN COMPLEX DURING WRN FACILITATED ATM ACTIVATION
Verlag:
LAP LAMBERT Academic Publishing Mär 2010, 2010
ISBN 10: 3838353617
ISBN 13: 9783838353616
Neu
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Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland
Verkäuferbewertung 5 von 5 Sternen
Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -WRN (Werner) protein is a member of the RecQ family showing helicase and exonuclease activity. WRN protein may lose function upon mutation and causes Werner syndrome (WS) which is a cancer-prone and premature aging disease. ATM (Ataxia-Telangiectasia mutated) protein initiates a signaling pathway in response to DNA double strand breaks (DSBs). Genomic disorder ataxia-telangiectasia (A-T) is associated with defective ATM. WRN protein is involved in ATM pathway activation when cells are exposed to DSBs associated with replication fork collapse. Because the Mre11-Rad50-Nbs1 (MRN) complex, a sensor of DSBs, is known to interact with WRN and ATM, we investigated whether the MRN complex mediates the WRN-dependent ATM pathway activation. In this study, we employed short-hairpin RNA to generate WRN- and Nbs1-deficient U-2 OS (osteosarcoma) cells. Cells were treated with clastogens which induce collapsed replication forks, thus provided proof for whether WRN facilitates ATM activation via MRN complex. This study serves as a basis for future investigation on the correlation between ATM, MRN complex and WRN, which will help understand the mechanism of aging and cancer.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 76 pp. Englisch. Bestandsnummer des Verkäufers 9783838353616
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