Identifying Genes That Encode APP Metabolism Modulators: A novel approach in functional genomics to gain insight into the pathogenesis of Alzheimer's disease - Softcover

Zhang, Can

 
9783838360898: Identifying Genes That Encode APP Metabolism Modulators: A novel approach in functional genomics to gain insight into the pathogenesis of Alzheimer's disease
Softcover
ISBN 10: 3838360893 ISBN 13: 9783838360898
Verlag: LAP LAMBERT Academic Publishing, 2010

Inhaltsangabe

Alzheimer?s disease (AD) is a devastating neurodegenerative disease with complex and strong genetic inheritance. The central pathological event in AD is believed to be the regulated intramembrane proteolysis of the amyloid-beta precursor protein (APP), which generates accumulable amyloid-beta peptide and the APP intracellular domain (AICD). The genetic cause of AD is not fully identified, and up to 70% of the heritability of AD is unknown. In this "translational" study, we hijacked the transcriptional activation property of the AICD fragment and constructed a functional assay to discover novel APP metabolism regulators. We have identified 11 positional candidate genes in an AD risk linkage region on chromosome 9 where the AD candidate gene, ubiquilin 1 (UBQLN1), has been previously found. Our data also showed that UBQLN1, which encodes a protein involved in protein degradation and quality control, modulates APP metabolism through a cell type-dependent mechanism. Collectively, we report a novel approach in functional genomics that provides a robust tool to identify novel AD candidate genes and may serve to provide insight into the pathogenesis of AD.

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Über die Autorin bzw. den Autor

Dr. Can Zhang is currently a research fellow at Harvard MedicalSchool and Massachusetts General Hospital after earning his M.D.and Ph.D. His research background includes a wide range offields, including neurodegenerative diseases, immunological andinfectious diseases. He has extensive expertise in research onAlzheimer's disease.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2010
Sprache
Englisch
ISBN 10 
3838360893
ISBN 13 
9783838360898
Einband
Taschenbuch
Anzahl der Seiten
156
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland