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Imatinib plasma concentrations variability in oncologic patients: Is imatinib a candidate drug for a therapeutic drug monitoring program? - Softcover

Widmer, Nicolas

 
9783838385112: Imatinib plasma concentrations variability in oncologic patients: Is imatinib a candidate drug for a therapeutic drug monitoring program?
Softcover
ISBN 10: 383838511X ISBN 13: 9783838385112
Verlag: LAP LAMBERT Academic Publishing, 2010

Inhaltsangabe

The anticancer drug imatinib has transformed the treatment and prognosis of chronic myeloid leukemia and gastrointestinal stromal tumor. However, the treatment must be taken indefinitely and is not devoid of inconveniences and toxicity. Moreover, resistance or escape from disease control are occurring. Considering the large interindividual differences in the function of the enzymatic and transport systems involved in imatinib disposition, exposure to this drug can be expected to vary widely among patients. This book describes an observational clinical trial aiming at exploring the influence of these covariates on imatinib pharmacokinetics and assessing the interindividual variability of the pharmacokinetic parameters of the drug. A large interindividual variability was observed, together with some preliminary concentration-effect relationships. These elements are arguments to further investigate the potential benefit of a therapeutic drug monitoring program to optimize the use of imatinib in patients. Such results should be especially useful to clinical oncologists or scientists involved in clinical oncology research.

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Über die Autorin bzw. den Autor

is a Swiss pharmacist who specialized both in Hospital Pharmacy and Clinical Pharmacology, and gained his PhD in Life Sciences in 2006. He is at present in charge of the Therapeutic Drug Monitoring service at the Division of Clinical Pharmacology and Toxicology (University Hospital Center and University of Lausanne).

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2010
Sprache
Englisch
ISBN 10 
383838511X
ISBN 13 
9783838385112
Einband
Taschenbuch
Anzahl der Seiten
248
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
info@bod.de
info@bod.de

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