Natural Antioxidants: An Approach Towards Tuberculosis Management: Green Tea Polyphenol (EGCG) as Potential Adjunct in Combating Mycobacterium tuberculosis Pathogenesis - Softcover

FATIMA, ZEESHAN

 
9783838394329: Natural Antioxidants: An Approach Towards Tuberculosis Management: Green Tea Polyphenol (EGCG) as Potential Adjunct in Combating Mycobacterium tuberculosis Pathogenesis
Softcover
ISBN 10: 3838394321 ISBN 13: 9783838394329
Verlag: LAP LAMBERT Academic Publishing, 2010

Inhaltsangabe

Tuberculosis (TB) has been reported to have fifth highest fatality rate in the world, a disease claiming between 2 and 3 million lives a year. One of the important reasons why this killer parasite is spiraling out of control at an alarming rate is attributed to the prevalence of multidrug-resistant (MDR) strains and emergence of AIDS-related TB. Focus has now been shifted towards development of compounds from natural sources that have antimycobacterial activity. The incorporation of such compounds, like polyphenols namely Epigallocatechin-3-gallate (EGCG) from green tea, as the natural component of tuberculosis treatments has been studied here. Reactive oxygen species and tumor necrosis factor (TNF-?) are the hallmarks of tuberculosis. The augmented expression of TNF-? at both the gene and protein levels in MTB-infected monocytes is suppressed by EGCG in dose-dependent manner. Also,EGCG ameliorated the IFN-? levels, the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF- ? in MTB-infected monocytes. Hence, EGCG may prove to be a valuable natural antioxidant in tuberculosis management.

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Über die Autorin bzw. den Autor

Postdoc Fellow, 2010: Dept of Cancer and Cell Bio,University of Cincinnati, Cincinnati, OH, USA. Research Associate, 2009: Parasite-Immun Lab, Dept of Biotechnology, Jamia Hamdard, New Delhi. Research Associate, 2008: Cytogenetics lab, Banaras Hindu University, Varanasi. Ph.D in Biochemistry: J.N.Medical College, Aligarh Muslim University, Aligarh, India.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2010
Sprache
Englisch
ISBN 10 
3838394321
ISBN 13 
9783838394329
Einband
Taschenbuch
Anzahl der Seiten
196
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

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Riga
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