DNA-binding aromatic drug molecules

 
9783843353892: DNA-binding aromatic drug molecules
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Aromatic molecules have been widely utilized in medicine as components of therapeutic drugs effective against various diseases. Of utmost importance now is the use of aromatic drugs in combination (combinational therapy), which leads to synergistic improvement of the chemotherapeutic index compared to when used alone (monotherapy). In the majority of cases the mechanisms of biological synergy are unknown or not explained at the cellular level. This review focuses on the biological role of direct intermolecular interaction of DNA-binding aromatic drug molecules, including their self-association, hetero- association, DNA complexation and specific molecular mechanisms operating in three-component systems, Drug1-Drug2-DNA. The theory of 'interceptor-protector' action is discussed, providing a molecular insight into the mechanisms of biological synergism. This monography should be useful for anyone working in the fields of biophysical and medicinal chemistry and dealing with interactions of DNA-targeting drug molecules.

Biografía del autor:

Maxim P.Evstigneev, PhD, DrSci, Professor of Physics and Biophysics at the Department of Physics, Sevastopol National Technical University (Ukraine). Head of biophysical group conducting research in the field of structure and thermodynamics of non-covalent interactions of DNA-binding drug molecules.

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Evstigneev, Maxim
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ISBN 10: 3843353891 ISBN 13: 9783843353892
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Buchbeschreibung LAP Lambert Acad. Publ. Okt 2010, 2010. Taschenbuch. Zustand: Neu. Neuware - Aromatic molecules have been widely utilized in medicine as components of therapeutic drugs effective against various diseases. Of utmost importance now is the use of aromatic drugs in combination (combinational therapy), which leads to synergistic improvement of the chemotherapeutic index compared to when used alone (monotherapy). In the majority of cases the mechanisms of biological synergy are unknown or not explained at the cellular level. This review focuses on the biological role of direct intermolecular interaction of DNA-binding aromatic drug molecules, including their self-association, hetero- association, DNA complexation and specific molecular mechanisms operating in three-component systems, Drug1-Drug2-DNA. The theory of interceptor-protector' action is discussed, providing a molecular insight into the mechanisms of biological synergism. This monography should be useful for anyone working in the fields of biophysical and medicinal chemistry and dealing with interactions of DNA-targeting drug molecules. 96 pp. Englisch. Bestandsnummer des Verkäufers 9783843353892

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Buchbeschreibung LAP Lambert Acad. Publ. Okt 2010, 2010. Taschenbuch. Zustand: Neu. Neuware - Aromatic molecules have been widely utilized in medicine as components of therapeutic drugs effective against various diseases. Of utmost importance now is the use of aromatic drugs in combination (combinational therapy), which leads to synergistic improvement of the chemotherapeutic index compared to when used alone (monotherapy). In the majority of cases the mechanisms of biological synergy are unknown or not explained at the cellular level. This review focuses on the biological role of direct intermolecular interaction of DNA-binding aromatic drug molecules, including their self-association, hetero- association, DNA complexation and specific molecular mechanisms operating in three-component systems, Drug1-Drug2-DNA. The theory of interceptor-protector' action is discussed, providing a molecular insight into the mechanisms of biological synergism. This monography should be useful for anyone working in the fields of biophysical and medicinal chemistry and dealing with interactions of DNA-targeting drug molecules. 96 pp. Englisch. Bestandsnummer des Verkäufers 9783843353892

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Buchbeschreibung LAP Lambert Acad. Publ. Okt 2010, 2010. Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Neuware - Aromatic molecules have been widely utilized in medicine as components of therapeutic drugs effective against various diseases. Of utmost importance now is the use of aromatic drugs in combination (combinational therapy), which leads to synergistic improvement of the chemotherapeutic index compared to when used alone (monotherapy). In the majority of cases the mechanisms of biological synergy are unknown or not explained at the cellular level. This review focuses on the biological role of direct intermolecular interaction of DNA-binding aromatic drug molecules, including their self-association, hetero- association, DNA complexation and specific molecular mechanisms operating in three-component systems, Drug1-Drug2-DNA. The theory of interceptor-protector' action is discussed, providing a molecular insight into the mechanisms of biological synergism. This monography should be useful for anyone working in the fields of biophysical and medicinal chemistry and dealing with interactions of DNA-targeting drug molecules. 96 pp. Englisch. Bestandsnummer des Verkäufers 9783843353892

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Buchbeschreibung LAP Lambert Academic Publishing, 2010. PAP. Zustand: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bestandsnummer des Verkäufers LQ-9783843353892

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