Stromal Cells Promote Bone Invasion in Ameloblastoma: stromal and tumor cell interaction and their subsequent role in bone invasion of ameloblastoma - Softcover

SATHI, GULSAN; Nagatsuka, Hitoshi

Softcover

ISBN 10: 3843357250 ISBN 13: 9783843357258

Verlag: LAP LAMBERT Academic Publishing, 2010

Inhaltsangabe

To date, there are many reports about the tumor progression and local invasion of ameloblastoma as well as bone resorption induced by the tumor cells. However, those studies have not described in detailed the histological features of ameloblastoma in terms of stroma and bone invasion. In this book therefore, discuss the stromal type with their sub types. In ameloblastoma, stroma acts not only in bone resorption but also causes suppression of new bone formation. sFRP-2, a Wnt antagonist is the main factor for the impaired bone formation. And activating RANKL with the help of TGF-?1 induced osteoclastogenesis. It causes bone destruction without a proportional osteoblastic reaction, resulting in an uncoupling of the normal bone remodeling sequence. So, the final volume of the bone destruction was less with a large number of osteoblast. Therapies targeting the inhibition of sFRP-2 and RANKL may potentials be used in inhibiting ameloblastoma's growth as well as other osteolytic disease.

Über diesen Titel

Über die Autorin bzw. den Autor

Gulsan Ara Sathi, B.D.S., PhD: Studied in oral pathology at Okayama University, Japan. Post-doctoral fellow at oral pathology, graduate school of medicine, dentistry and pharmaceutical science, okayama university, Japan

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2010
• Sprache: Englisch
• ISBN 10: 3843357250
• ISBN 13: 9783843357258
• Einband: Taschenbuch
• Anzahl der Seiten: 56
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: VDM Verlag Dr. Müller; customerservice@vdm-vsg.de; ; Brivibas gatve 197; Riga; 1039; Lettland