In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent: Designing & Synthesis of Novel Target-MurB Inhibitors as Antibacterial Agents - Softcover
Inhaltsangabe
Heterobicyclic oxazolo pyrimidinone are important class of compounds. They may become promising candidates for exploiting more useful therapeutically active molecules. The compounds having oxazolo pyrimidinone moiety are associated with interesting wide spectrum biological activities, such as antibacterial, kinase inhibition, adenosine receptor antagonism, tumour growth inhibition and some show to inhibit the ability of ricin to inactivate the ribosomes etc. The intermediate azlactones are also useful precursors for the synthesis of amino acids, peptides, heterocycles, biosensors and antitumor or antimicrobial compounds. In the present study, it was proposed to synthesize lead molecules of oxazolo pyrimidinone skeleton, apt for binding to the target enzyme, bacterial MurB based on the rational approach and to study their docking simulations using ArgusLab 4.0.1 and AutoDock 4.2 softwares. The synthesized test compounds were then characterized by TLC, melting point determination, UV, IR, 1H-NMR and mass spectral studies and tested for their antibacterial activity and compare with the standard drug.
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Über die Autorin bzw. den Autor
I have completed M.Pharm (Pharm. Chemistry) from Gujarat Technological University, Gujarat (India). Currently working as a Research Associate Scientist in Piramal Discovery Solutions. I have expertise in Drug designing & also have sound knowledge of Chemistry. My research work is dedicated to my PARENTS.
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In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent
Verlag:
LAP LAMBERT Academic Publishing Apr 2012, 2012
ISBN 10: 3843371091
ISBN 13: 9783843371094
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Heterobicyclic oxazolo pyrimidinone are important class of compounds. They may become promising candidates for exploiting more useful therapeutically active molecules. The compounds having oxazolo pyrimidinone moiety are associated with interesting wide spectrum biological activities, such as antibacterial, kinase inhibition, adenosine receptor antagonism, tumour growth inhibition and some show to inhibit the ability of ricin to inactivate the ribosomes etc. The intermediate azlactones are also useful precursors for the synthesis of amino acids, peptides, heterocycles, biosensors and antitumor or antimicrobial compounds. In the present study, it was proposed to synthesize lead molecules of oxazolo pyrimidinone skeleton, apt for binding to the target enzyme, bacterial MurB based on the rational approach and to study their docking simulations using ArgusLab 4.0.1 and AutoDock 4.2 softwares. The synthesized test compounds were then characterized by TLC, melting point determination, UV, IR, 1H-NMR and mass spectral studies and tested for their antibacterial activity and compare with the standard drug. 148 pp. Englisch. Bestandsnummer des Verkäufers 9783843371094
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In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3843371091
ISBN 13: 9783843371094
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: PATEL SANJAYI have completed M.Pharm (Pharm. Chemistry) from Gujarat Technological University, Gujarat (India). Currently working as a Research Associate Scientist in Piramal Discovery Solutions. I have expertise in Drug designing & . Bestandsnummer des Verkäufers 5467022
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In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent
Verlag:
LAP LAMBERT Academic Publishing Apr 2012, 2012
ISBN 10: 3843371091
ISBN 13: 9783843371094
Neu
Taschenbuch
Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Heterobicyclic oxazolo pyrimidinone are important class of compounds. They may become promising candidates for exploiting more useful therapeutically active molecules. The compounds having oxazolo pyrimidinone moiety are associated with interesting wide spectrum biological activities, such as antibacterial, kinase inhibition, adenosine receptor antagonism, tumour growth inhibition and some show to inhibit the ability of ricin to inactivate the ribosomes etc. The intermediate azlactones are also useful precursors for the synthesis of amino acids, peptides, heterocycles, biosensors and antitumor or antimicrobial compounds. In the present study, it was proposed to synthesize lead molecules of oxazolo pyrimidinone skeleton, apt for binding to the target enzyme, bacterial MurB based on the rational approach and to study their docking simulations using ArgusLab 4.0.1 and AutoDock 4.2 softwares. The synthesized test compounds were then characterized by TLC, melting point determination, UV, IR, 1H-NMR and mass spectral studies and tested for their antibacterial activity and compare with the standard drug.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 148 pp. Englisch. Bestandsnummer des Verkäufers 9783843371094
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In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent : Designing & Synthesis of Novel Target-MurB Inhibitors as Antibacterial Agents
Verlag:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3843371091
ISBN 13: 9783843371094
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Heterobicyclic oxazolo pyrimidinone are important class of compounds. They may become promising candidates for exploiting more useful therapeutically active molecules. The compounds having oxazolo pyrimidinone moiety are associated with interesting wide spectrum biological activities, such as antibacterial, kinase inhibition, adenosine receptor antagonism, tumour growth inhibition and some show to inhibit the ability of ricin to inactivate the ribosomes etc. The intermediate azlactones are also useful precursors for the synthesis of amino acids, peptides, heterocycles, biosensors and antitumor or antimicrobial compounds. In the present study, it was proposed to synthesize lead molecules of oxazolo pyrimidinone skeleton, apt for binding to the target enzyme, bacterial MurB based on the rational approach and to study their docking simulations using ArgusLab 4.0.1 and AutoDock 4.2 softwares. The synthesized test compounds were then characterized by TLC, melting point determination, UV, IR, 1H-NMR and mass spectral studies and tested for their antibacterial activity and compare with the standard drug. Bestandsnummer des Verkäufers 9783843371094
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In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent | Designing & Synthesis of Novel Target-MurB Inhibitors as Antibacterial Agents
Verlag:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3843371091
ISBN 13: 9783843371094
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Taschenbuch. Zustand: Neu. In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent | Designing & Synthesis of Novel Target-MurB Inhibitors as Antibacterial Agents | Sanjay Patel (u. a.) | Taschenbuch | 148 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783843371094 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 106485172
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In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent: Designing & Synthesis of Novel Target-MurB Inhibitors as Antibacterial Agents
Verlag:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3843371091
ISBN 13: 9783843371094
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