Detection of Anti malarial IgG/IgG subclasses in sudanies patients: Detection of Antimalarial IgG/IgG subclass in relationship to ABO blood group and haematological changes in Sudanese Patients - Softcover

Mohamed El.Toum El.Sheisk, Mona

Softcover

ISBN 10: 384338178X ISBN 13: 9783843381789

Verlag: LAP LAMBERT Academic Publishing, 2011

Inhaltsangabe

Merozoite surface protein MSP2 is avaccine candidate antigen of Plasmodium falciparum that is polymorphic in natural populations. In this study we aimed to investigate whether malaria infection in associated with anti-malaria specific IgG, using recombinant proteins derived from the two major allelic types of MSP2 and ABO blood group. The conclusion is the Higher anti-malarial IgG1, IgG3, IgG2 and lower levels of IgG4 were associated with reduced risk of malaria infection. IgG2 is activator of the classical complement pathway, Fc?RIIa H131 is essential for handling IgG2 immune complexes. These data suggest that an MSP2 based vaccine should be designed to induce high level antibody responses against the different MSP2 types present globally in P. falciparum populations and that MSP2 could be combined with other P. falciparum antigens to form a multi-component malaria vaccine.

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Reseña del editor

Merozoite surface protein MSP2 is avaccine candidate antigen of Plasmodium falciparum that is polymorphic in natural populations. In this study we aimed to investigate whether malaria infection in associated with anti-malaria specific IgG, using recombinant proteins derived from the two major allelic types of MSP2 and ABO blood group. The conclusion is the Higher anti-malarial IgG1, IgG3, IgG2 and lower levels of IgG4 were associated with reduced risk of malaria infection. IgG2 is activator of the classical complement pathway, FcγRIIa H131 is essential for handling IgG2 immune complexes. These data suggest that an MSP2 based vaccine should be designed to induce high level antibody responses against the different MSP2 types present globally in P. falciparum populations and that MSP2 could be combined with other P. falciparum antigens to form a multi-component malaria vaccine.

Biografía del autor

(Say that my prayer and my sacrifice and my life and my death to Allah, Lord of the Worlds) To my parents,family,friends and every one believed on me and who participated in giving birth to this work.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2011
• Sprache: Englisch
• ISBN 10: 384338178X
• ISBN 13: 9783843381789
• Einband: Tapa blanda
• Anzahl der Seiten: 68
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar