RNA interference pathways in the moss Physcomitrella patens: The regulatory role of small RNAs in the moss Physcomitrella patens - Softcover

Khraiwesh, Basel

 
9783844325188: RNA interference pathways in the moss Physcomitrella patens: The regulatory role of small RNAs in the moss Physcomitrella patens
Softcover
ISBN 10: 3844325182 ISBN 13: 9783844325188
Verlag: LAP LAMBERT Academic Publishing, 2011

Inhaltsangabe

RNA interference (RNAi) is a mechanism regulating gene transcript levels by either transcriptional gene silencing (TGS) or by posttranscriptional gene silencing (PTGS), which acts in genome maintenance and the regulation of development. This book show the role of Dicer proteins in the moss Physcomitrella patens, which has four Dicers (DICER-LIKE 1a (DCL1a), DCL1b, DCL3 and DCL4). The Physcomitrella patens was chosen because the dual functions of Dicers in miRNA biogenesis and target cleavage are separable in this species. Using targeted knockout-mutants of Physcomitrella patens, it was shown that DCL1a is required for miRNA biogenesis and DCL1b is required for miRNA-induced target RNA cleavage. Based on these data from Physcomitrella patens a model is proposed for the gene-specific control of transcription factors upon dysfunctions of the RNAi machinery. Similar control mechanisms could be exist in other eukaryotes as well. Also this book provide evidence that artificial miRNAs (amiRNAs) can be used as an alternative tool for studying gene functions in Physcomitrella patens.

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Über die Autorin bzw. den Autor

Dr. Basel Khraiwesh is Postdoctoral Fellow at the Plant StressGenomic and Technology Research Center at KAUST University. Hehas previously worked at other academic institutions such as theVIB Department of Plant Systems Biology, Ghent University,Belgium and he earned a doctorate in Plant Biotechnology,University of Freiburg, Germany in 2009.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2011
Sprache
Englisch
ISBN 10 
3844325182
ISBN 13 
9783844325188
Einband
Taschenbuch
Anzahl der Seiten
128
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Edicoes Nosso Conhecimento
customerservice@vdm-vsg.de

SIA
Riga
1039
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