HPTLC Method Development and Validation: Analytical Method Development and Validation - Softcover

Mardia, Rajnikant; Pasha, T. Y.; Suhagia, B. N.

 
9783844327359: HPTLC Method Development and Validation: Analytical Method Development and Validation
Softcover
ISBN 10: 3844327355 ISBN 13: 9783844327359
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

Simultaneous quantification of Lopinavir and Ritonavir in tablet by HPTLC method was developed and validated .The chromatograms were developed using a mobile phase of Chloroform: 1, 4 - Dioxane (7:3 %v/v) on pre-coated plate of silica gel GF aluminum TLC plate and quantified by densitometric absorbance mode at 210 nm. The Rf value for lopinavir and ritonavir was 0.74 and 0.58 respectively. The linearity of the method was found to be within the concentration range of 160-960 ng/spot for Lopinavir and for Ritonavir, it was 40-240 ng/spot. The lower limits of detection and quantification were 9.56 ng/spot and 28.96 ng/spot for Lopinavir and 6.82 ng/spot and 20.66 ng/spot for Ritonavir. The method was also validated for precision, specificity and recovery. This developed method was used to analyze fixed-dose tablet (Lopimune, Cipla Ltd) sample of Lopinavir and Ritonavir.

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Über die Autorin bzw. den Autor

At presently working as senior assistant professor at Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India. I have completed my Ph.D. under the guidance of Dr. T. Y. Pasha and B. N. Suhagia from Saurashtra University, Rajkot,in December- 2012. I have 1 national and 6 international papers published.I have presented 5 papers.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3844327355
ISBN 13 
9783844327359
Einband
Taschenbuch
Anzahl der Seiten
64
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