Development of Self Microemulsifying Drug Delivery System: Preparation and evaluation of Lovastatin Self Microemulsifying Drug Delivery System - Softcover

Patel, Mr.Maulik; Sanjay Patel, Dr.; Natvarlal Patel, Dr.

 
9783844331820: Development of Self Microemulsifying Drug Delivery System: Preparation and evaluation of Lovastatin Self Microemulsifying Drug Delivery System
Softcover
ISBN 10: 3844331824 ISBN 13: 9783844331820
Verlag: LAP LAMBERT Academic Publishing, 2011

Inhaltsangabe

Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate of the drug. However, these methods have their own limitations. In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drugs. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS).

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Reseña del editor

Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate of the drug. However, these methods have their own limitations. In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drugs. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS).

Biografía del autor

Mr. Maulik J. Patel (Assistant Professor, Pharmaceutics Department), Dr. Sanjay S. Patel, (Associate Professor, Pharmaceutics Department) and Dr. Natvarlal M. Patel (Principal) working in Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa – 383315, India

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2011
Sprache
Englisch
ISBN 10 
3844331824
ISBN 13 
9783844331820
Einband
Tapa blanda
Anzahl der Seiten
104
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Nicht verfügbar

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