Verwandte Artikel zu DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTIC...

DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES: Ionotropic Gelation and Double Desolvation Technique - Softcover

Singh, Vandana; Chaudhary, Amrendra; Ahmed, Shamim

 
9783844393682: DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES: Ionotropic Gelation and Double Desolvation Technique
Softcover
ISBN 10: 3844393684 ISBN 13: 9783844393682
Verlag: LAP LAMBERT Academic Publishing, 2011

Inhaltsangabe

Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.

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Über die Autorin bzw. den Autor

Mrs. Vandana Singh graduated from Dr.K.N.M.I.P.E.R, Modinagar, and post graduated from Bundelkhand University, Jhansi. She is having 1 year of industrial and 4 years of teaching experience. Currently working as Senior Lecturer at Translam Institute of Pharmaceutical Education and Research, Meerut, India.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2011
Sprache
Englisch
ISBN 10 
3844393684
ISBN 13 
9783844393682
Einband
Taschenbuch
Anzahl der Seiten
92
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Dictus Publishing
Customerservice@vdm-vsg.de

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Riga
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