Studies on Andrographolide from Andrographis paniculata: Extraction, Development and Characterization of AR K562 cell lines - Softcover

Avanigadda, Sumanjali; Meena Vangalapati, Dr

 
9783846505533: Studies on Andrographolide from Andrographis paniculata: Extraction, Development and Characterization of AR K562 cell lines
Softcover
ISBN 10: 3846505536 ISBN 13: 9783846505533
Verlag: LAP LAMBERT Academic Publishing, 2011

Inhaltsangabe

Andrographolide is the main diterpenoid lactone contained in the leaves of Andrographis paniculata. This bioactive component has multifunctional medicinal properties such as activity against fever, dysentery, diarrhoea, inflammation, cancer and sore throat as well as immune disorder. No solvent is ideal for the extraction of Andrographolide, however we can consider 60% methanol for the model development. Cancer is the largest single cause of death in both men and women, claiming over 6 million each year in the world. CML accounts for about 20% cases of adult and childhood leukemia. Andrographolide acts by targeting the tyrosine kinase activity of BCR-ABL which represents a very promising therapeutic strategy in chronic myeloid leukemia (CMML). In the present study, we focused on amplifying the ABL kinase domain sequence and b2a2 junction domain sequence and tried to find out the sequence difference between normal K562 cells and AR-K562 cells .for this we developed resistant cell lines against Andrographolide by gradual increase in the in the concentration of Andrographolide (1nm to 1um), the morphological features were studied in phase contrast microscopy.

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Über die Autorin bzw. den Autor

Sumanjali Avanigadda is research scholar under the guidance of Dr. Meena Vangalapati, published three research papers. Dr. Meena Vangalapati M.Tech, Ph.D, Associate Professor from Department of Chemical Engineering, Andhra University, Visakhapatnam, India. She had teaching experience of 10 years and published 35 more research papers.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2011
Sprache
Englisch
ISBN 10 
3846505536
ISBN 13 
9783846505533
Einband
Taschenbuch
Anzahl der Seiten
140
Kontakt zum Hersteller
Nicht verfügbar
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