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HPLC Method Validation Benzofuran Derivatives: Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline - Softcover

Thorat, Bapu; Yamgar, Ramesh; More, Kishor

 
9783846519660: HPLC Method Validation Benzofuran Derivatives: Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline
Softcover
ISBN 10: 3846519669 ISBN 13: 9783846519660
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

Number of methods are known for the the synthesis of the natural product 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde are known. It is conveniently synthesized by using Intramolecular Wittig reaction of ester. Reductive amination is one of the versatile method for the synthesis of secondary or tertiary amines from aldehydes or ketones by using suitable reducing agent in one-pot fashion. This reaction has been carried out at room temperature and in acidic medium (by using acetic acid). 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde was reacted with 3-fluoroaniline in ethylene dichloride in presence of catalytic amount of acetic acid forming 3-fluoro-N-{[7-methoxy-2-(4-methoxyphenyl)-1-benzofuran-5-yl]methyl}aniline. It is novel benzofuran amine. It's HPLC method validation has been carried out and apply to series of compounds.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3846519669
ISBN 13 
9783846519660
Einband
Taschenbuch
Anzahl der Seiten
60
Kontakt zum Hersteller
SIA OmniScriptum Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland