Modified alpha-beta Chimeric OligoDNA as a Unique Class of TFO: A Study on Synthesis and Properties of alpha-beta Chimeric OligoDNA - Softcover

Azam, A.T.M. Zafrul

Softcover

ISBN 10: 3846532460 ISBN 13: 9783846532461

Verlag: LAP LAMBERT Academic Publishing, 2011

Inhaltsangabe

A series of novel alpha-beta chimeric oligodeoxynucleotides bearing either an intercalator-conjugated nucleobase located at the internal 4-nt linker region or an anthraquinone-conjugated propionic acid as a non-nucleosidic backbone unit at the internal linker region was synthesized. The UV-melting experiments reveled that the obtained modified chimera TFOs formed remarkably stable alternate-stranded triplex. On the other hand, modified TFOs bearing non-nucleosidic intercalator-conjugate possessed two diastereomers formed substantially stable alternate-stranded triple helix almost regardless of the stereochemistry of the incorporated non-nucleosidic backbone unit. The sequence discrimination ability and thermodynamic stability of some TFOs were also examined.

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Über die Autorin bzw. den Autor

Dr. Azam is working as an Assoc. Prof. for Faculty of Pharmacy, University of Dhaka, Bangladesh. His research interest is in Nucleic Acids and Medicinal Chemistry. He obtained his B.Pharm.(Hons.) and M.Pharm. from Univ. of Dhaka, Bangladesh; PhD from Gunma Univ., Japan. He worked as a JSPS Post-Doctoral research Fellow at Kanagawa Univ., Japan.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2011
• Sprache: Englisch
• ISBN 10: 3846532460
• ISBN 13: 9783846532461
• Einband: Taschenbuch
• Anzahl der Seiten: 160
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: SIA OmniScriptum Publishing; customerservice@vdm-vsg.de; ; Brivibas gatve 197; Riga; 1039; Lettland