A Virtual Screening & Molecular Docking Study of Thiadiazoles:: Inhibitory activity of Thiadiazoles on Protein Kinase PKnB from Mycobacterium Tuberculosis - Softcover

Raj, Utkarsh; Kumari, Monika; Naqvi, S.A.H

 
9783846584859: A Virtual Screening & Molecular Docking Study of Thiadiazoles:: Inhibitory activity of Thiadiazoles on Protein Kinase PKnB from Mycobacterium Tuberculosis
Softcover
ISBN 10: 3846584851 ISBN 13: 9783846584859
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

In structure-based drug design, the three-dimensional structure of a drug target interacting with small molecules is used to guide drug discovery. "Structure-based drug design represents the idea that you can see exactly how your molecule interacts with its target protein."This structural information can be obtained with X-ray crystallography or nuclear magnetic resonance spectroscopy (NMR). Originally, structure-based drug design was equated with de novo design or building a molecule from the ground up. Structure-based drug design relies on knowledge of the three dimensional structure of the biological target obtained through methods such as x-ray crystallography or NMR spectroscopy. If an experimental structure of a target is not available, it may be possible to create a homology model of the target based on the experimental structure of a related protein. As experimental methods such as X-ray crystallography and NMR develop, the amount of information concerning 3D structures of biomolecular targets has increased dramatically. Current methods for structure-based drug design can be divided roughly into two categories : Ligand-based drug design & receptor-based drug design.

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Über die Autorin bzw. den Autor

I am pursuing M.Tech Biotech from GBU,India.My area of interests are CAAD,Microarray Analysis etc.I had done various projects which got accepted at National / International level & got two publications in Journal of Computational Intelligence in Bioinformatics.I am also working as RA at BCS-Insilico Biology,Lucknow & imparting training to students.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3846584851
ISBN 13 
9783846584859
Einband
Taschenbuch
Anzahl der Seiten
56
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Nicht verfügbar
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