Diclofenac Na Matrix Tablet: Formulation Development and Release Kinetics Study - Softcover

Ahmed, Tajnin

Softcover

ISBN 10: 3847336894 ISBN 13: 9783847336891

Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

In this research work sustained release Diclofenac Sodium matrix tablets were prepared by using different polymers like Kollidon SR, Poly Ethylene Glycol and HPMC at different percentages. 5 batches of 260mg tablets were prepared by direct compression and wet granulation methods and by using different shapes in an attempt towards modification of dissolution behavior of the drug. The used shapes of tablets were caplet oval, round oval add flat oval. Dissolution study of each of the formulation was monitored at pH 1.2, 6.5 and 7.4. An increase drug release took place in case of higher pH i.e. at pH 7.4 & pH 6.5 but in lower pH i.e. at pH 1.2 a little amount of drug release was obtained. Due to the acidic nature if drug its release was lower at acidic pH. Again in case of shape at higher pH 6.5 & 7.4 the release was better from the caplet oval shape than that of round oval and flat oval. A cooperative higher release of drug was obtained from the polymer HPMC at 10% from the Diclofenac Sodium matrix tablet, which contain fixed amount of Kollidon SR, which was 30% them that of the PEG of 10%. The drug release was also found to be better in case of direct compression method.

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Über die Autorin bzw. den Autor

Tajnin Ahmed obtained her M.Pharm degree in Pharmaceutical Science from University of Science and Technology, Bangladesh. Currently she is working as an Asst. Prof. in the Dept. of Pharmacy, Stamford University Bangladesh (SUB). Mohammad Abusyed is working in ICDDR,B as Business Development Manager. Dewan T. Akhtar is Lecturer in SUB.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2012
• Sprache: Englisch
• ISBN 10: 3847336894
• ISBN 13: 9783847336891
• Einband: Taschenbuch
• Anzahl der Seiten: 128
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: SIA OmniScriptum Publishing; customerservice@vdm-vsg.de; ; Brivibas gatve 197; Riga; 1039; Lettland