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Detection of Methylated RAR in the Urine of Bladder Cancer Patients: Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine - Softcover
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Bladder cancer is an important public health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer patients, so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of RARβ2 tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated RARβ2 gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary RARβ2 promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of RARβ2 promoter hypermethylation was (83.6%) and the specificity was (89.7%), while the sensitivity of urine cytology was (52.2%). Combined use of detection of urinary RARβ2 promoter hypermethylation with urine cytology increased the sensitivity of cytology from 52.2% to 89.5%.
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Ass-lecturer of biochemistry- faculty of pharmacy, Misr University for Science and Technology . Coauthor: Sanaa Eissa:Prof of medical biochemistry and molecular biology at Ain Shams University Faculty of medicineLeading research in developing novel diagnostic tests for bladder cancer with 51 international publications
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Detection of Methylated RAR in the Urine of Bladder Cancer Patients
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LAP LAMBERT Academic Publishing Jan 2012, 2012
ISBN 10: 3847379240
ISBN 13: 9783847379249
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Bladder cancer is an important public health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer patients, so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of RAR 2 tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated RAR 2 gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary RAR 2 promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of RAR 2 promoter hypermethylation was (83.6%) and the specificity was (89.7%), while the sensitivity of urine cytology was (52.2%). Combined use of detection of urinary RAR 2 promoter hypermethylation with urine cytology increased the sensitivity of cytology from 52.2% to 89.5%. 248 pp. Englisch. Bestandsnummer des Verkäufers 9783847379249
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Detection of Methylated RAR in the Urine of Bladder Cancer Patients
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3847379240
ISBN 13: 9783847379249
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Ibrahim AhmedAss-lecturer of biochemistry- faculty of pharmacy, Misr University for Science and Technology . Coauthor: Sanaa Eissa:Prof of medical biochemistry and molecular biology at Ain Shams University Faculty of medicineLeading. Bestandsnummer des Verkäufers 5514416
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Detection of Methylated RAR in the Urine of Bladder Cancer Patients | Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine
Verlag:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3847379240
ISBN 13: 9783847379249
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Taschenbuch. Zustand: Neu. Detection of Methylated RAR in the Urine of Bladder Cancer Patients | Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine | Ahmed Ibrahim (u. a.) | Taschenbuch | 248 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783847379249 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 106644771
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Detection of Methylated RAR in the Urine of Bladder Cancer Patients
Verlag:
LAP LAMBERT Academic Publishing Jan 2012, 2012
ISBN 10: 3847379240
ISBN 13: 9783847379249
Neu
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Bladder cancer is an important public health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer patients, so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of RAR¿2 tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated RAR¿2 gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary RAR¿2 promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of RAR¿2 promoter hypermethylation was (83.6%) and the specificity was (89.7%), while the sensitivity of urine cytology was (52.2%). Combined use of detection of urinary RAR¿2 promoter hypermethylation with urine cytology increased the sensitivity of cytology from 52.2% to 89.5%.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 248 pp. Englisch. Bestandsnummer des Verkäufers 9783847379249
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Detection of Methylated RAR in the Urine of Bladder Cancer Patients : Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine
Verlag:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3847379240
ISBN 13: 9783847379249
Neu
Taschenbuch
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Bladder cancer is an important public health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer patients, so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of RAR 2 tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated RAR 2 gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary RAR 2 promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of RAR 2 promoter hypermethylation was (83.6%) and the specificity was (89.7%), while the sensitivity of urine cytology was (52.2%). Combined use of detection of urinary RAR 2 promoter hypermethylation with urine cytology increased the sensitivity of cytology from 52.2% to 89.5%. Bestandsnummer des Verkäufers 9783847379249
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Detection of Methylated RAR in the Urine of Bladder Cancer Patients: Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine
Verlag:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3847379240
ISBN 13: 9783847379249
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