Preparation and Solid-State Characterization of Leflunomide Polymorph: Tiwari et al. leflunomide polymorph along with its solubility assessment - Softcover

Tiwari, Gaurav; Tiwari, Ruchi; Bhati, Lokesh

 
9783848419500: Preparation and Solid-State Characterization of Leflunomide Polymorph: Tiwari et al. leflunomide polymorph along with its solubility assessment
Softcover
ISBN 10: 3848419505 ISBN 13: 9783848419500
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

Leflunomide is a drug with limited water solubility. It exhibits four polymorphic forms I,II,III,IV. In the present study, form II polymorph was formulated using form I. Form II polymorph readily dissolves in water than does form I. The crystals of form I and II polymorph were characterized by IR, DSC, XRPD. Comparison of solubility of form I and form II was done by UV Spectrophotometer. There was a significant increase in solubility of form II. Aqueous film-coated tablets of form I and form II were prepared using the same processing parameters and compared for the rate of dissolution. Form II tablets showed a significant improvement in terms of dissolution rate, drug release and solubility.

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Über die Autorin bzw. den Autor

O Dr. Gaurav Tiwari é Professor Associado no Departamento de Farmácia do Instituto de Tecnologia Pranveer Singh, Kanpur. Ele tem mais de 8 livros e 13 patentes em seu crédito.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3848419505
ISBN 13 
9783848419500
Einband
Taschenbuch
Anzahl der Seiten
132
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
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