Analysis of Some Phosphorus Containing Compounds in Pharmaceuticals: Analytical Determination of Alendronate, Etidronate and Risedronate in Drug Substance and Pharmaceutical Preparations - Softcover

El-Shaheny, Rania; Walash, Mohamed; Eid, Manal

Softcover

ISBN 10: 3848422751 ISBN 13: 9783848422753

Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

Among phosphorus containing pharmaceutical compounds, bisphosphonates is a very important class. Therapeutic uses of bisphosphonates include maagement of malignancy-associated hypercalcemia, treatment of postmenopausal osteoporosis and cancer. Bisphosphonates, as a group of active pharmaceutical compounds, generally "give headache" to analytical chemists. The two phosphonic groups per molecule lend a strongly ionic character and increased polarity to these compounds. Additionally, the majority of the members of this family lacks of chromophores, or even has a weak one, excluding convenient sensitive UV or fluorescence detection.This work is devoted to the determination of three bisphosphonate drugs commercially available in the local Egyptian market (alendronate, etidronate and risedronate.The usefulness of different spectrophotometric and chromatographic methods was exploited.The proposed methods are of great value in quality control analysis of the studied compounds owing to their improved simplicity, sensitivity, low-cost, and its independence on expensive instruments, or critical analytical reagents.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2012
• Sprache: Englisch
• ISBN 10: 3848422751
• ISBN 13: 9783848422753
• Einband: Taschenbuch
• Anzahl der Seiten: 188
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Fromm; customerservice@vdm-vsg.de; ; Brivibas gatve 197; Riga; 1039; Lettland