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Heam Polymerization and its Inhibition by Antimalarial Drug: Hemozoin is considered to be a suitable target to develop new antimalarial drug - Softcover
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Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether.
Biografía del autor
Sanjeev Kumar Shukla is completed his Ph.D. in Biotechnology, B.U. Jhansi,U.P., India, Ramesh Chandra is completed his Ph.D. in Zoology at CDRI, Lucknow, India and S.K.Puri is a Head,Division of Parasitology, CDRI, Lucknow India.
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- VerlagLAP LAMBERT Academic Publishing
- Erscheinungsdatum2012
- ISBN 10 3848433974
- ISBN 13 9783848433971
- EinbandTapa blanda
- Anzahl der Seiten64
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Heam Polymerization and its Inhibition by Antimalarial Drug: Hemozoin is considered to be a suitable target to develop new antimalarial drug
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ISBN 13: 9783848433971
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Heam Polymerization and its Inhibition by Antimalarial Drug Hemozoin is considered to be a suitable target to develop new antimalarial drug
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Heam Polymerization and Its Inhibition by Antimalarial Drug
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ISBN 13: 9783848433971
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Heam Polymerization and Its Inhibition by Antimalarial Drug
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Heam Polymerization and its Inhibition by Antimalarial Drug Hemozoin is considered to be a suitable target to develop new antimalarial drug
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Heam Polymerization and its Inhibition by Antimalarial Drug
Verlag:
LAP Lambert Academic Publishing, 2012
ISBN 10: 3848433974
ISBN 13: 9783848433971
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether. 64 pp. Englisch. Bestandsnummer des Verkäufers 9783848433971
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Heam Polymerization and its Inhibition by Antimalarial Drug : Hemozoin is considered to be a suitable target to develop new antimalarial drug
Verlag:
LAP Lambert Academic Publishing, 2012
ISBN 10: 3848433974
ISBN 13: 9783848433971
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether. Bestandsnummer des Verkäufers 9783848433971
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Heam Polymerization and its Inhibition by Antimalarial Drug
Verlag:
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ISBN 10: 3848433974
ISBN 13: 9783848433971
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Shukla Sanjeev KumarSanjeev Kumar Shukla is completed his Ph.D. in Biotechnology, B.U. Jhansi,U.P., India, Ramesh Chandra is completed his Ph.D. in Zoology at CDRI, Lucknow, India and S.K.Puri is a Head,Division of Parasitology, CDRI. Bestandsnummer des Verkäufers 5521867
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Heam Polymerization and its Inhibition by Antimalarial Drug: Hemozoin is considered to be a suitable target to develop new antimalarial drug
Verlag:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3848433974
ISBN 13: 9783848433971
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