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Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM.
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Michael received his B.S. with honors in Neuroscience from the University of California - Los Angeles and then then attended New York Medical College where he completed a combined MD/PhD degree. Currently he is a resident in the Department of Neurosurgery at the University of Utah.
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
Verlag:
LAP LAMBERT Academic Publishing Feb 2014, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM. 256 pp. Englisch. Bestandsnummer des Verkäufers 9783848487530
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Karsy MichaelMichael received his B.S. with honors in Neuroscience from the University of California - Los Angeles and then then attended New York Medical College where he completed a combined MD/PhD degree. Currently he is a reside. Bestandsnummer des Verkäufers 5526405
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The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
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The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
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LAP LAMBERT Academic Publishing, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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Taschenbuch. Zustand: Neu. The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma | Michael Karsy | Taschenbuch | 256 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783848487530 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 105425830
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The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
Verlag:
LAP LAMBERT Academic Publishing Feb 2014, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
Neu
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 256 pp. Englisch. Bestandsnummer des Verkäufers 9783848487530
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
Verlag:
LAP LAMBERT Academic Publishing, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM. Bestandsnummer des Verkäufers 9783848487530
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The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
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ISBN 13: 9783848487530
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