Controlled Permeable Polymersomes Decorated with Functional-Antennae for Biomedical Applications - Hardcover

Yassin, Mohamed A.

Hardcover

ISBN 10: 3944331877 ISBN 13: 9783944331874

Verlag: TUDpress, 2014

Inhaltsangabe

In the context of diligent efforts to improve the tumor targeting efficiency of drug carriers, a shape-persistent polymersome which possess a pH-tunable membrane as well as folate targeting antennae is reported. The membrane of such polymersomes behaves as gate which undergoes “on” and “off” switches in response to pH stimuli. Thus, polymersomes can effectively prohibit the premature release of chemotherapeutic agents such as doxorubicin in physiological conditions, but promote drug release once they are triggered in the acidified endosomal compartment. Importantly, the folate moieties are installed on the surface of polymersomes as protruding antennae by doping the polymersomes with folate-terminated block copolymers designed to have longer PEG segments. Thereby, the folate moieties are freed from concealment and steric effects exerted by the dense PEG corona. The cellular uptake of the FAantennae polymersomes by tumor cells is signifi cantly enhanced facilitated by the freely accessible folate antennae; however, the normal cells record a low level of cellular uptake due to the stealth property of the PEG corona. Overall, the excellent biocompatibility, controlled permeability, targeted internalization, as well as selective cytotoxicity of such polymersomes set up the basis for properly smart carrier for targeted drug delivery.

Details zur Ausgabe

• Verlag: TUDpress
• Erscheinungsdatum: 2014
• Sprache: Englisch
• ISBN 10: 3944331877
• ISBN 13: 9783944331874
• Einband: Gebundene Ausgabe
• Auflage: 1
• Anzahl der Seiten: 165
• Kontakt zum Hersteller: mail@thelem.de; mail@thelem.de; ; Hüblerstraße 26; Dresden; 01309; Deutschland